How cells dedifferentiate: A lesson from plants

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109 Scopus citations


The remarkable regenerative capacity displayed by plants and various vertebrates, such as amphibians, is largely based on the capability of somatic cells to undergo dedifferentiation. In this process, mature cells reverse their state of differentiation and acquire pluripotentiality - a process preceding not only reentry into the cell cycle but also a commitment for cell death or trans- or redifferentiation. Recent studies provide a new perspective on cellular dedifferentiation, establishing chromatin reorganization as its fundamental theme.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalDevelopmental Biology
Issue number1
StatePublished - 1 Apr 2004
Externally publishedYes


  • Amphibians
  • Cell cycle
  • Cellular dedifferentiation
  • Chromatin remodeling
  • Plants
  • Pluripotentiality
  • Regeneration
  • Retinoblastoma
  • Thrombin

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology


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