HOW DOES LITHIUM WORK ON MANIC DEPRESSION? clinical and psychological correlates of the inositol theory

R. H. Belmaker, Yuly Bersudsky, Galila Agam, Joseph Levine, Ora Kofman

Research output: Contribution to journalReview articlepeer-review

62 Scopus citations

Abstract

How lithium works in manic-depressive illness is unknown. Recently, however, a powerful hypothesis has been gaining momentum. Distinguished by its testability and clinical implications, the inositol depletion hypothesis of lithium action is relevant to treatment of lithium side effects, to the development of new compounds with the clinical profile of lithium, and to new experimental treatment of depression.

Original languageEnglish
Pages (from-to)47-56
Number of pages10
JournalAnnual Review of Medicine
Volume47
DOIs
StatePublished - 20 May 1996

Keywords

  • Inositol
  • Lithium
  • Manic depression

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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