HOW DOES LITHIUM WORK ON MANIC DEPRESSION? clinical and psychological correlates of the inositol theory

R. H. Belmaker; Yuly Bersudsky; Galila Agam; Joseph Levine; Ora Kofman

doi:10.1146/annurev.med.47.1.47

HOW DOES LITHIUM WORK ON MANIC DEPRESSION? clinical and psychological correlates of the inositol theory

R. H. Belmaker, Yuly Bersudsky, Galila Agam, Joseph Levine, Ora Kofman

Research output: Contribution to journal › Review article › peer-review

60 Scopus citations

Abstract

How lithium works in manic-depressive illness is unknown. Recently, however, a powerful hypothesis has been gaining momentum. Distinguished by its testability and clinical implications, the inositol depletion hypothesis of lithium action is relevant to treatment of lithium side effects, to the development of new compounds with the clinical profile of lithium, and to new experimental treatment of depression.

Original language	English
Pages (from-to)	47-56
Number of pages	10
Journal	Annual Review of Medicine
Volume	47
DOIs	https://doi.org/10.1146/annurev.med.47.1.47
State	Published - 20 May 1996

Keywords

Inositol
Lithium
Manic depression

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10.1146/annurev.med.47.1.47

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abstract = "How lithium works in manic-depressive illness is unknown. Recently, however, a powerful hypothesis has been gaining momentum. Distinguished by its testability and clinical implications, the inositol depletion hypothesis of lithium action is relevant to treatment of lithium side effects, to the development of new compounds with the clinical profile of lithium, and to new experimental treatment of depression.",

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AU - Levine, Joseph

AU - Kofman, Ora

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AB - How lithium works in manic-depressive illness is unknown. Recently, however, a powerful hypothesis has been gaining momentum. Distinguished by its testability and clinical implications, the inositol depletion hypothesis of lithium action is relevant to treatment of lithium side effects, to the development of new compounds with the clinical profile of lithium, and to new experimental treatment of depression.

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KW - Lithium

KW - Manic depression

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HOW DOES LITHIUM WORK ON MANIC DEPRESSION? clinical and psychological correlates of the inositol theory

Abstract

Keywords

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