How to control an intracellular proteolytic system: Coordinated regulatory switches in the mycobacterial Pup-proteasome system

Eyal Gur, Maayan Korman, Nir Hecht, Ofir Regev, Shai Schlussel, Nimrod Silberberg, Yifat Elharar

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Intracellular proteolysis is critical for the proper functioning of all cells, owing to its involvement in a wide range of processes. Because of the destructive nature of protein degradation, intracellular proteolysis is restricted by control mechanisms at almost every step of the proteolytic process. Understanding the coordination of such mechanisms is a challenging task, especially in systems as complex as the eukaryotic ubiquitin-proteasome system (UPS). In comparison, the bacterial analog of the UPS, the Pup-proteasome system (PPS) is much simpler and, therefore, allows for insight into the control of a proteolytic system. This review integrates available information to present a coherent picture of what is known of PPS regulatory switches and describes how these switches act in concert to enforce regulation at the system level. Finally, open questions regarding PPS regulation are discussed, providing readers with a sense of what lies ahead in the field.

Original languageEnglish
Pages (from-to)2253-2260
Number of pages8
JournalBiochimica et Biophysica Acta - Molecular Cell Research
Volume1864
Issue number12
DOIs
StatePublished - 1 Dec 2017

Keywords

  • Dop
  • PafA
  • Proteasome
  • Proteolysis
  • Pup

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