H2S release of covalent peptide hydrogels triggered by human neutrophil elastase (HNE)

Mingjun Zhou, Yun Qian, Yumeng Zhu, Ronit Bitton, John B Matson, Yin Wang, John B Matson

Research output: Contribution to journalArticlepeer-review

Abstract

We report a novel HNE-responsive H2S-releasing hydrogel material by covalently crosslinking biopolymers with an HNE-degradable peptide. Due to the cleavage of the peptide with HNE, a gel-sol transition was triggered to expose encapsulated S-aroylthiooxime (SATO) groups to cysteine, leading to higher H2S-releasing peaking concentration and longer peaking time,
compared to the release profile without HNE. More interestingly, after consuming the SATO groups on the surface of the hydrogel, the H2S release can be resumed by adding HNE, which
shows potential applications in treating chronic disease with recurring inflammation. Furthermore, the H2S-releasing behavior can be tuned by adjusting the polymer composition, leading to different crosslinking density, hydrogel stiffness, SATO loading, as well as release rate and peaking time. Our work presents a novel synthetic strategy for H2S-releasing materials, as well as important insight into the enzyme-degradable hydrogels.
Original languageEnglish GB
Pages (from-to)138
Number of pages1
JournalElastin-Like Peptide Dendrimers: Design, Synthesis, and Applications
StatePublished - 2019

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