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HU-331, a novel cannabinoid-based anticancer topoisomerase II inhibitor
Natalya M. Kogan
, Michael Schlesinger
,
Esther Priel
, Ruth Rabinowitz
, Eduard Berenshtein
, Mordechai Chevion
, Raphael Mechoulam
School of Medical Laboratory Science
The Shraga Segal Department of Microbiology, Immunology and Genetics
Research output
:
Contribution to journal
›
Article
›
peer-review
70
Scopus citations
Overview
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Keyphrases
Cannabinoids
100%
Anticancer
100%
Topoisomerase Inhibitors
100%
HU-331
100%
Quinones
42%
Cancer Cell Lines
28%
DNA Topoisomerase
28%
In Cancer
14%
Highly Effective
14%
Mode of Action
14%
Cell Death
14%
Mechanism of Action
14%
Cell Cycle Arrest
14%
Anticancer Drugs
14%
Cell Apoptosis
14%
Nanomolar Concentrations
14%
High Efficacy
14%
Cancer Therapy
14%
Nude Mice
14%
Specific Inhibitor
14%
Unique Mechanism
14%
Apoptosis Activation
14%
Topoisomerase II
14%
Cannabidiol
14%
Anthracyclines
14%
Intermediate Species
14%
Reactive Oxygen Intermediates
14%
Cancer Cell Cycle
14%
Caspase Activation
14%
Quinonoid
14%
Reactive Oxygen Species Generation
14%
Tumorgrafts
14%
Pharmacology, Toxicology and Pharmaceutical Science
Malignant Neoplasm
100%
Gyrase Inhibitor
100%
Cannabinoid
100%
DNA Topoisomerase (ATP Hydrolysing)
33%
Neoplasm
16%
Anticarcinogen
16%
Caspase
16%
Reactive Oxygen Metabolite
16%
Nude Mouse
16%
DNA Topoisomerase
16%
Cannabidiol
16%
Anthracycline
16%
Quinone Derivative
16%
Mode of Action
16%