Human alpha 1-antitrypsin attenuates injury-induced Inflammation through interacting with high mobility group box-1 (HMGB1)

David E. Ohayon; Ronen Schuster; Mark I. Mizrahi; Yotann Lior; Boris M. Baranovski; Galit Shahaf; Eli C. Lewis

Human alpha 1-antitrypsin attenuates injury-induced Inflammation through interacting with high mobility group box-1 (HMGB1)

David E. Ohayon, Ronen Schuster, Mark I. Mizrahi, Yotann Lior, Boris M. Baranovski, Galit Shahaf, Eli C. Lewis

Research output: Contribution to journal › Meeting Abstract › peer-review

Abstract

HMGB1 is involved in pathologies such as cellular injury and autoimmunity. Indeed, upon binding to immune-related receptors, HMGB1 promotes an inflammatory response, such as that might take part in pancreatic islet destruction during both autoimmune diabetes and islet transplant rejection. Specifically, elevated circulating HMGB1 levels were reported in patients with type 1 diabetes, and increased release of HMGB1 was found to correlate with injury degree and islet allograft survival. The anti-inflammatory and immune-modulatory acute-phase protein human α1-antitrypsin (hAAT) promotes islet survival in both transplantation and autoimmune diabetes models. While AAT binds to damage-released proteins, such as gp96 and HSP70, its tissue protective mechanism remains poorly understood. We now extend this observation that AAT protective activity is related to its interaction with HMGB1. Clinical-grade AAT …

Original language	English
Pages (from-to)	82.31-82.31
Number of pages	1
Journal	Journal of Immunology
Volume	198
Issue number	Supplement1
State	Published - 1 May 2017

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title = "Human alpha 1-antitrypsin attenuates injury-induced Inflammation through interacting with high mobility group box-1 (HMGB1)",

abstract = "HMGB1 is involved in pathologies such as cellular injury and autoimmunity. Indeed, upon binding to immune-related receptors, HMGB1 promotes an inflammatory response, such as that might take part in pancreatic islet destruction during both autoimmune diabetes and islet transplant rejection. Specifically, elevated circulating HMGB1 levels were reported in patients with type 1 diabetes, and increased release of HMGB1 was found to correlate with injury degree and islet allograft survival. The anti-inflammatory and immune-modulatory acute-phase protein human α1-antitrypsin (hAAT) promotes islet survival in both transplantation and autoimmune diabetes models. While AAT binds to damage-released proteins, such as gp96 and HSP70, its tissue protective mechanism remains poorly understood. We now extend this observation that AAT protective activity is related to its interaction with HMGB1. Clinical-grade AAT …",

author = "Ohayon, {David E.} and Ronen Schuster and Mizrahi, {Mark I.} and Yotann Lior and Baranovski, {Boris M.} and Galit Shahaf and Lewis, {Eli C.}",

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T1 - Human alpha 1-antitrypsin attenuates injury-induced Inflammation through interacting with high mobility group box-1 (HMGB1)

AU - Ohayon, David E.

AU - Schuster, Ronen

AU - Mizrahi, Mark I.

AU - Lior, Yotann

AU - Baranovski, Boris M.

AU - Shahaf, Galit

AU - Lewis, Eli C.

PY - 2017/5/1

Y1 - 2017/5/1

N2 - HMGB1 is involved in pathologies such as cellular injury and autoimmunity. Indeed, upon binding to immune-related receptors, HMGB1 promotes an inflammatory response, such as that might take part in pancreatic islet destruction during both autoimmune diabetes and islet transplant rejection. Specifically, elevated circulating HMGB1 levels were reported in patients with type 1 diabetes, and increased release of HMGB1 was found to correlate with injury degree and islet allograft survival. The anti-inflammatory and immune-modulatory acute-phase protein human α1-antitrypsin (hAAT) promotes islet survival in both transplantation and autoimmune diabetes models. While AAT binds to damage-released proteins, such as gp96 and HSP70, its tissue protective mechanism remains poorly understood. We now extend this observation that AAT protective activity is related to its interaction with HMGB1. Clinical-grade AAT …

AB - HMGB1 is involved in pathologies such as cellular injury and autoimmunity. Indeed, upon binding to immune-related receptors, HMGB1 promotes an inflammatory response, such as that might take part in pancreatic islet destruction during both autoimmune diabetes and islet transplant rejection. Specifically, elevated circulating HMGB1 levels were reported in patients with type 1 diabetes, and increased release of HMGB1 was found to correlate with injury degree and islet allograft survival. The anti-inflammatory and immune-modulatory acute-phase protein human α1-antitrypsin (hAAT) promotes islet survival in both transplantation and autoimmune diabetes models. While AAT binds to damage-released proteins, such as gp96 and HSP70, its tissue protective mechanism remains poorly understood. We now extend this observation that AAT protective activity is related to its interaction with HMGB1. Clinical-grade AAT …

M3 - Meeting Abstract

SN - 0022-1767

VL - 198

SP - 82.31-82.31

JO - Journal of Immunology

JF - Journal of Immunology

IS - Supplement1

ER -

Human alpha 1-antitrypsin attenuates injury-induced Inflammation through interacting with high mobility group box-1 (HMGB1)

Abstract

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