TY - JOUR
T1 - Human NK cell recognition of target cells in the prism of natural cytotoxicity receptors and their ligands
AU - Brusilovsky, Michael
AU - Rosental, Benyamin
AU - Shemesh, Avishai
AU - Appel, Michael Y.
AU - Porgador, Angel
PY - 2012/7/1
Y1 - 2012/7/1
N2 - The matter of the pathogen- and cancer-associated ligands recognized by the Natural Cytotoxicity Receptors (NCRs) has been a subject of intense research ever since the identification of the NCRs more than 12 years ago by Alessandro and Lorenzo Moretta: NKp46 in 1997, NKp44 in 1998, and finally NKp30 in 1999. Expression patterns recognized by NCRs include pathogen-derived, pathogen-induced, and cancer-associated cellular 'self' ligands. Pathogen-exposed cells may exhibit both types of pathogen-associated ligands. Transformed cells, in contrast, exhibit only 'self' ligands which are derived from both the intracellular- and membrane-associated milieu of self molecules. These expression patterns allow for NCR-based NK cell discrimination between healthy and affected cells, in the realms of both pathogenic infection and potential tumorigenesis. The focus of this review is on the current knowledge regarding the identities of NCR ligands and the type of target cells expressing these ligands.
AB - The matter of the pathogen- and cancer-associated ligands recognized by the Natural Cytotoxicity Receptors (NCRs) has been a subject of intense research ever since the identification of the NCRs more than 12 years ago by Alessandro and Lorenzo Moretta: NKp46 in 1997, NKp44 in 1998, and finally NKp30 in 1999. Expression patterns recognized by NCRs include pathogen-derived, pathogen-induced, and cancer-associated cellular 'self' ligands. Pathogen-exposed cells may exhibit both types of pathogen-associated ligands. Transformed cells, in contrast, exhibit only 'self' ligands which are derived from both the intracellular- and membrane-associated milieu of self molecules. These expression patterns allow for NCR-based NK cell discrimination between healthy and affected cells, in the realms of both pathogenic infection and potential tumorigenesis. The focus of this review is on the current knowledge regarding the identities of NCR ligands and the type of target cells expressing these ligands.
KW - Cancer
KW - Ligand
KW - Natural Cytotoxicity Receptor (NCR)
KW - Natural Killer (NK) cells
KW - Viral infection
KW - Virus
KW - receptors
UR - http://www.scopus.com/inward/record.url?scp=84865312352&partnerID=8YFLogxK
U2 - 10.3109/1547691X.2012.675366
DO - 10.3109/1547691X.2012.675366
M3 - Article
C2 - 22524686
AN - SCOPUS:84865312352
SN - 1547-691X
VL - 9
SP - 267
EP - 274
JO - Journal of Immunotoxicology
JF - Journal of Immunotoxicology
IS - 3
ER -
