Abstract
Peritonitis caused by Candida albicans is a major complication of continuous ambulatory peritoneal dialysis (CAPD). Increasing the activity of the peritoneal macrophages- the predominant cell type found in the peritoneal cavity-may be of great importance in the prevention and therapy of peritonitis. Therefore, the activating effect of tuftsin was studied on human peritoneal macrophages from CAPD patients. Tuftsin induced a biphasic effect on macrophage activity within a range of 2×10-9-2×10-6M, with a maximal activity 2×10-7M. At this concentration,tuftsin enhanced by twofold cell association with radiolabelled candida (from 2±0.2 to 4±0.2 candida per macrophage) and superoxide anion production in response to exposure to candida (from 150±20 to 300±20 nmoles/mg). These results suggest the potential use of tuftsin as a therapeutic drug.
Original language | English |
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Pages (from-to) | 257-261 |
Number of pages | 5 |
Journal | Immunology Letters |
Volume | 21 |
Issue number | 3 |
DOIs | |
State | Published - 1 Jun 1989 |
Keywords
- Candida association
- Peritoneal macrophages
- Tuftsin
- superoxide production
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology