Humanized affinity-matured monoclonal antibody 8H9 has potent antitumor activity and binds to FG loop of tumor antigen B7-H3

Mahiuddin Ahmed; Ming Cheng; Qi Zhao; Yehuda Goldgur; Sarah M. Cheal; Hong Fen Guo; Steven M. Larson; Nai Kong V. Cheung

doi:10.1074/jbc.M115.679852

Humanized affinity-matured monoclonal antibody 8H9 has potent antitumor activity and binds to FG loop of tumor antigen B7-H3

Mahiuddin Ahmed, Ming Cheng, Qi Zhao, Yehuda Goldgur, Sarah M. Cheal, Hong Fen Guo, Steven M. Larson, Nai Kong V. Cheung

Research output: Contribution to journal › Article › peer-review

89 Scopus citations

Abstract

Background: B7-H3 is an immune inhibitory ligand and an antigen on many solid tumors. Results: Antibody 8H9 was humanized and affinity-matured, and its epitope was mapped to the FG loop of B7-H3. Conclusion: hu8H9 antibodies had potent antitumor activity and may modulate immune inhibitory properties of B7-H3. Significance: Antibodies were developed to target solid tumors and affect immune checkpoint blockade.

Original language	English
Pages (from-to)	30018-30029
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	290
Issue number	50
DOIs	https://doi.org/10.1074/jbc.M115.679852
State	Published - 11 Dec 2015
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M115.679852

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title = "Humanized affinity-matured monoclonal antibody 8H9 has potent antitumor activity and binds to FG loop of tumor antigen B7-H3",

abstract = "Background: B7-H3 is an immune inhibitory ligand and an antigen on many solid tumors. Results: Antibody 8H9 was humanized and affinity-matured, and its epitope was mapped to the FG loop of B7-H3. Conclusion: hu8H9 antibodies had potent antitumor activity and may modulate immune inhibitory properties of B7-H3. Significance: Antibodies were developed to target solid tumors and affect immune checkpoint blockade.",

author = "Mahiuddin Ahmed and Ming Cheng and Qi Zhao and Yehuda Goldgur and Cheal, {Sarah M.} and Guo, {Hong Fen} and Larson, {Steven M.} and Cheung, {Nai Kong V.}",

note = "Publisher Copyright: {\textcopyright} 2015 by The American Society for Biochemistry and Molecular Biology, Inc.",

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doi = "10.1074/jbc.M115.679852",

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T1 - Humanized affinity-matured monoclonal antibody 8H9 has potent antitumor activity and binds to FG loop of tumor antigen B7-H3

AU - Ahmed, Mahiuddin

AU - Cheng, Ming

AU - Zhao, Qi

AU - Goldgur, Yehuda

AU - Cheal, Sarah M.

AU - Guo, Hong Fen

AU - Larson, Steven M.

AU - Cheung, Nai Kong V.

PY - 2015/12/11

Y1 - 2015/12/11

N2 - Background: B7-H3 is an immune inhibitory ligand and an antigen on many solid tumors. Results: Antibody 8H9 was humanized and affinity-matured, and its epitope was mapped to the FG loop of B7-H3. Conclusion: hu8H9 antibodies had potent antitumor activity and may modulate immune inhibitory properties of B7-H3. Significance: Antibodies were developed to target solid tumors and affect immune checkpoint blockade.

AB - Background: B7-H3 is an immune inhibitory ligand and an antigen on many solid tumors. Results: Antibody 8H9 was humanized and affinity-matured, and its epitope was mapped to the FG loop of B7-H3. Conclusion: hu8H9 antibodies had potent antitumor activity and may modulate immune inhibitory properties of B7-H3. Significance: Antibodies were developed to target solid tumors and affect immune checkpoint blockade.

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U2 - 10.1074/jbc.M115.679852

DO - 10.1074/jbc.M115.679852

M3 - Article

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SP - 30018

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JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 50

ER -

Humanized affinity-matured monoclonal antibody 8H9 has potent antitumor activity and binds to FG loop of tumor antigen B7-H3

Abstract

ASJC Scopus subject areas

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