Humanized affinity-matured monoclonal antibody 8H9 has potent antitumor activity and binds to FG loop of tumor antigen B7-H3

Mahiuddin Ahmed, Ming Cheng, Qi Zhao, Yehuda Goldgur, Sarah M. Cheal, Hong Fen Guo, Steven M. Larson, Nai Kong V. Cheung

Research output: Contribution to journalArticlepeer-review

61 Scopus citations

Abstract

Background: B7-H3 is an immune inhibitory ligand and an antigen on many solid tumors. Results: Antibody 8H9 was humanized and affinity-matured, and its epitope was mapped to the FG loop of B7-H3. Conclusion: hu8H9 antibodies had potent antitumor activity and may modulate immune inhibitory properties of B7-H3. Significance: Antibodies were developed to target solid tumors and affect immune checkpoint blockade.

Original languageEnglish
Pages (from-to)30018-30029
Number of pages12
JournalJournal of Biological Chemistry
Volume290
Issue number50
DOIs
StatePublished - 11 Dec 2015
Externally publishedYes

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