Hydrogel Reinforced by Short Albumin Fibers Mechanical Characterization and Assessment of Biocompatibility

Chaganti Srinivasa Reddy, Nora Nseir, Eyal Zussman, Oren Regev

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Injectable hydrogels represent biomaterials attractive for many biomedical applications. Here, a hybrid material composed of dextran-crosslinked gelatin embedded with approximate to 1001000 mu m long, electrospun bovine serum albumin fibers is described. Incorporation of fibers at weight fractions of 16% increases the hydrogel elastic modulus by up to approximate to 40% and decreases the gelation time by approximate to 20%. The addition of short fibers does not affect the injection of the pre-gel solution throughout medical needles at moderate shear rates. Finally, viability of seeded fibroblasts confirms the biocompatibility of the composite scaffold. This hybrid represents a class of biomaterials that structurally mimics the ECMs of common tissues and that can be delivered by a minimal-invasive approach.
Original languageEnglish
Pages (from-to)283-291
Number of pages9
JournalMacromolecular Materials and Engineering
Volume298
Issue number3
StatePublished - 2013

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