TY - JOUR
T1 - Hydrogen bonding patterns of the co-crystal containing the pharmaceutically active ingredient isoniazid and terephthalic acid
AU - Lemmerer, Andreas
AU - Bernstein, Joel
AU - Kahlenberg, Volker
N1 - Funding Information:
Acknowledgements This work was supported in part by Grant No. 2004118 from the United States–Israel Binational Science Foundation (Jerusalem). A. L. thanks the South African National Research Foundation for a postdoctoral scholarship (SFP2007070400002) and the Oppenheimer Memorial Trust for funding. The authors thank Dr. Dmitry Mogilyanski (Ben-Gurion University of the Negev) for powder diffraction work.
PY - 2011/7/1
Y1 - 2011/7/1
N2 - The title co-crystal (terephthalic acid)•(isonicotinic acid hydrazide)2 was prepared by solution methods and solvent-assisted grinding. The crystal belongs to the monoclinic space group P21/c with a = 6.2395(4), b = 3.7705(3), c = 41.220(3) Å and β = 94.494(6)°. X-ray single crystal structure analysis reveals that the carboxylic acid•••pyridine heterosynthon is utilized to co-crystallize the anti-tubercolosis drug isoniazid with the co-crystal former terephthalic acid. The co-crystal crystallizes out as needles, and the homosynthons associated with the isoniazid and the π stacking of the terephthalic acid produce fastest crystal growth in the direction of the needle axis, corresponding to the short (∼3.7 Å) b crystallographic axis.
AB - The title co-crystal (terephthalic acid)•(isonicotinic acid hydrazide)2 was prepared by solution methods and solvent-assisted grinding. The crystal belongs to the monoclinic space group P21/c with a = 6.2395(4), b = 3.7705(3), c = 41.220(3) Å and β = 94.494(6)°. X-ray single crystal structure analysis reveals that the carboxylic acid•••pyridine heterosynthon is utilized to co-crystallize the anti-tubercolosis drug isoniazid with the co-crystal former terephthalic acid. The co-crystal crystallizes out as needles, and the homosynthons associated with the isoniazid and the π stacking of the terephthalic acid produce fastest crystal growth in the direction of the needle axis, corresponding to the short (∼3.7 Å) b crystallographic axis.
KW - Co-crystal
KW - Graph sets
KW - Hydrogen bonding
KW - Solvent-assisted grinding
KW - X-ray crystallography
UR - http://www.scopus.com/inward/record.url?scp=79958038786&partnerID=8YFLogxK
U2 - 10.1007/s10870-011-0031-9
DO - 10.1007/s10870-011-0031-9
M3 - Article
AN - SCOPUS:79958038786
SN - 1074-1542
VL - 41
SP - 991
EP - 997
JO - Journal of Chemical Crystallography
JF - Journal of Chemical Crystallography
IS - 7
ER -