Hydroxylation with Ozone on Silica Gel. The Synthesis of 1α, 25-Dihydroxyvitamin D3

Zvi Cohen; Ehud Keinan; Yehuda Mazur; Aharon Ulman

doi:10.1021/jo00877a035

Hydroxylation with Ozone on Silica Gel. The Synthesis of 1α, 25-Dihydroxyvitamin D₃

Zvi Cohen, Ehud Keinan, Yehuda Mazur, Aharon Ulman

Research output: Contribution to journal › Letter › peer-review

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Abstract

A convenient synthesis of 1α,25-dihydroxyvitamin D₃, the natural calcium regulating hormone, based on a regioselective C₂₅-hydroxylation of 1α,3β-diacetoxy-6β,7α-dibromocholestane by means of ozone absorbed on silica gel, is reported.

Original language	English
Pages (from-to)	2651-2652
Number of pages	2
Journal	Journal of Organic Chemistry
Volume	41
Issue number	15
DOIs	https://doi.org/10.1021/jo00877a035
State	Published - 1 Jul 1976
Externally published	Yes

ASJC Scopus subject areas

Organic Chemistry

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10.1021/jo00877a035

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title = "Hydroxylation with Ozone on Silica Gel. The Synthesis of 1α, 25-Dihydroxyvitamin D3",

abstract = "A convenient synthesis of 1α,25-dihydroxyvitamin D3, the natural calcium regulating hormone, based on a regioselective C25-hydroxylation of 1α,3β-diacetoxy-6β,7α-dibromocholestane by means of ozone absorbed on silica gel, is reported.",

author = "Zvi Cohen and Ehud Keinan and Yehuda Mazur and Aharon Ulman",

year = "1976",

month = jul,

day = "1",

doi = "10.1021/jo00877a035",

language = "English",

volume = "41",

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journal = "Journal of Organic Chemistry",

issn = "0022-3263",

publisher = "American Chemical Society",

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T1 - Hydroxylation with Ozone on Silica Gel. The Synthesis of 1α, 25-Dihydroxyvitamin D3

AU - Cohen, Zvi

AU - Keinan, Ehud

AU - Mazur, Yehuda

AU - Ulman, Aharon

PY - 1976/7/1

Y1 - 1976/7/1

N2 - A convenient synthesis of 1α,25-dihydroxyvitamin D3, the natural calcium regulating hormone, based on a regioselective C25-hydroxylation of 1α,3β-diacetoxy-6β,7α-dibromocholestane by means of ozone absorbed on silica gel, is reported.

AB - A convenient synthesis of 1α,25-dihydroxyvitamin D3, the natural calcium regulating hormone, based on a regioselective C25-hydroxylation of 1α,3β-diacetoxy-6β,7α-dibromocholestane by means of ozone absorbed on silica gel, is reported.

UR - http://www.scopus.com/inward/record.url?scp=0017142935&partnerID=8YFLogxK

U2 - 10.1021/jo00877a035

DO - 10.1021/jo00877a035

M3 - Letter

AN - SCOPUS:0017142935

SN - 0022-3263

VL - 41

SP - 2651

EP - 2652

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 15

ER -

Hydroxylation with Ozone on Silica Gel. The Synthesis of 1α, 25-Dihydroxyvitamin D₃

Abstract

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