Hyperthyroidism association with SLE, lessons from real-life data - A case-control study

Abdulla Watad, Arnon D. Cohen, Doron Comaneshter, Dorit Tekes-Manova, Howard Amital

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Background: Despite the frequently encountered association between thyroid disease and systemic lupus erythematosus (SLE) is well known, it is of surprise that only several reports compromised of small population size support this observation. Objectives: To investigate the association of comorbid SLE and hyperthyroidism. Methods: Using the database of the largest health maintenance organization (HMO) in Israel, the Clalit Health Services, we searched for the co-existence of SLE and hyperthyroidism. Patients with SLE were compared with age- and sex-matched controls regarding the prevalence of hyperthyroidism in a case-control study. Chi-square and t-tests were used for univariate analysis and a logistic regression model was used for multivariate analysis. Results: The study included 5018 patients with SLE and 25 090 age- and sex- matched controls. The prevalence of hyperthyroidism in patients with SLE was increased compared with the prevalence in controls (2.59% and 0.91%, respectively, p < 0.001). In a multivariate analysis, SLE was associated with hyperthyroidism (odds ratio 2.52, 95% confidence interval 2.028-3.137). Conclusions: Patients with SLE have a greater prevalence of hyperthyroidism than matched controls. Therefore, physicians treating patients with SLE should be aware of this possibility of this thyroid dysfunction.

Original languageEnglish
Pages (from-to)17-20
Number of pages4
Issue number1
StatePublished - 2 Jan 2016


  • Autoimmune disease
  • SLE
  • comorbidity
  • hyperthyroidism
  • thyroid dysfunction


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