Hypolipidemic effect of [6]-Gingerol-loaded Eudragit polymeric nanoparticles in high-fat diet-induced rats and Gamma scintigraphy evaluation of gastric-retention time

Virendra Singh, Himanshu Pandey, Vatsala Misra, Vandana Tiwari, Pallavi Srivastava, Devendra Singh

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

[6]-Gingerol is the potent pharmacological active phytocompound of ginger. The essential role of [6]-gingerol in drug therapy is limited due to its poor water solubility and low bioavailability. Hence, [6]-gingerol-loaded Eudragit nanoparticles were prepared by using a single emulsification solvent evaporation method to overcome hepatic firstpass metabolism and to increase oral bioavailability. The study was designed to investigate the anti-hyperlipidemic potential of [6]-gingerol in rats fed a high-fat diet (HFD). The hypolipidemic potential of [6]-gingerol at a dose of 25 and 50 mg/kg was evaluated in HFD-induced hyperlipidemic rats. The results of the study were surprisingly intriguing with [6]-gingerol significantly (p≤ 0.005), altering the serum total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol levels to near-normal in HFD-induced hyperlipidemic rats. The TC and TG were also significantly reduced after treatment with 25 and 50 mg/kg of [6]-gingerol as compared to standard atorvastatin treatment. Gamma scintigraphy results were promising with 24-hour gastric-retention time. The novel formulation [6]-gingerol-loaded Eudragit polymeric nanoparticle has a significant potential to be used as a green antihyperlipidemic agent.

Original languageEnglish
Pages (from-to)156-163
Number of pages8
JournalJournal of Applied Pharmaceutical Science
Volume12
Issue number6
DOIs
StatePublished - 1 Jun 2022
Externally publishedYes

Keywords

  • Atorvastatin
  • Gamma scintigraphy
  • Hypolipidemic
  • Nanoformulation
  • [6]-Gingerol

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Pharmacology, Toxicology and Pharmaceutics (all)
  • Pharmacology (medical)

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