Hyporeninemic hypoaldosteronism associated with multiple myeloma: 11 years of follow-up

Y. Shaked, A. Blau, O. Shpilberg, Y. Samra

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Hyporeninemic hypoaldosteronism is an important underlying condition, causing hyperkalemia with hyperchloremic metabolic acidosis, disproportionate to the degree of renal insufficiency present. The principal defect in this syndrome is a reduced level of plasma renin activity, which results in secondary hypoaldosteronism. Diabetes mellitus is usually the primary underlying renal disease, though other causes of renal diseases associated with this syndrome have been described. This case report describes for the first time an elderly patient with multiple myeloma, in remission for more than 11 years, associated with the syndrome of hyporeninemic hypoaldosteronism at the time of diagnosis. The complete resolution of the syndrome after vigorous chemotherapy is an intriguing possibility.

Original languageEnglish
Pages (from-to)79-82
Number of pages4
JournalClinical Nephrology
Issue number2
StatePublished - 1 Jan 1993
Externally publishedYes


  • Hyporeninemic hypoaldosteronism
  • Multiple myeloma

ASJC Scopus subject areas

  • Nephrology


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