Hypothyroidism among SLE patients: Case-control study

Abdulla Watad, Naim Mahroum, Aaron Whitby, Smadar Gertel, Doron Comaneshter, Arnon D. Cohen, Howard Amital

Research output: Contribution to journalReview articlepeer-review

36 Scopus citations


Background: The prevalence of hypothyroidism in SLE patients varies considerably and early reports were mainly based on small cohorts. Objectives: To investigate the association between SLE and hypothyroidism. Methods: Patients with SLE were compared with age and sex-matched controls regarding the proportion of hypothyroidism in a case-control study. Chi-square and t-tests were used for univariate analysis and a logistic regression model was used for multivariate analysis. The study was performed utilizing the medical database of Clalit Health Services. Results: The study included 5018 patients with SLE and 25,090 age and sex-matched controls. The proportion of hypothyroidism in patients with SLE was increased compared with the prevalence in controls (15.58% and 5.75%, respectively, P < 0.001). In a multivariate analysis, SLE was associated with hypothyroidism (odds ratio 2.644, 95% confidence interval 2.405-2.908). Conclusions: Patients with SLE have a greater proportion of hypothyroidism than matched controls. Therefore, physicians treating patients with SLE should be aware of the possibility of thyroid dysfunction.

Original languageEnglish
Pages (from-to)484-486
Number of pages3
JournalAutoimmunity Reviews
Issue number5
StatePublished - 1 May 2016


  • Autoimmune disease
  • Hypothyroidism
  • Polyautoimmunity
  • SLE
  • Thyroid dysfunction


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