Identification of compounds which inhibit cytotoxicity associated with mutant Huntingtin protein expression

Steve Titus; Natalie Elia; Noel Southall; Wei Zheng; Juan Jose Marugan; Marcy MacDonald

Identification of compounds which inhibit cytotoxicity associated with mutant Huntingtin protein expression

Steve Titus, Natalie Elia, Noel Southall, Wei Zheng, Juan Jose Marugan, Marcy MacDonald

Department of Life Sciences

Research output: Book/Report › Book › peer-review

Abstract

In this report, we present data on a compound, ML168 (CID 2432214), which is able to protect cells from cytotoxicity induced by the expression of a large mutant poly-Q expansion Huntingtin (HTT) protein by inhibiting the activation of the intrinsic apoptotic pathway. This probe can be used in cellular assays and ex vivo experiments to study and inhibit the initiation of apoptosis induced by the expression of mutant, cytotoxic HTT protein. This probe will be of great interest to the scientific community that studies Huntington’s disease and other neurodegenerative diseases.

Original language	English
State	Published - 2010

Cite this

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title = "Identification of compounds which inhibit cytotoxicity associated with mutant Huntingtin protein expression",

abstract = "In this report, we present data on a compound, ML168 (CID 2432214), which is able to protect cells from cytotoxicity induced by the expression of a large mutant poly-Q expansion Huntingtin (HTT) protein by inhibiting the activation of the intrinsic apoptotic pathway. This probe can be used in cellular assays and ex vivo experiments to study and inhibit the initiation of apoptosis induced by the expression of mutant, cytotoxic HTT protein. This probe will be of great interest to the scientific community that studies Huntington{\textquoteright}s disease and other neurodegenerative diseases.",

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year = "2010",

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TY - BOOK

T1 - Identification of compounds which inhibit cytotoxicity associated with mutant Huntingtin protein expression

AU - Titus, Steve

AU - Elia, Natalie

AU - Southall, Noel

AU - Zheng, Wei

AU - Marugan, Juan Jose

AU - MacDonald, Marcy

PY - 2010

Y1 - 2010

N2 - In this report, we present data on a compound, ML168 (CID 2432214), which is able to protect cells from cytotoxicity induced by the expression of a large mutant poly-Q expansion Huntingtin (HTT) protein by inhibiting the activation of the intrinsic apoptotic pathway. This probe can be used in cellular assays and ex vivo experiments to study and inhibit the initiation of apoptosis induced by the expression of mutant, cytotoxic HTT protein. This probe will be of great interest to the scientific community that studies Huntington’s disease and other neurodegenerative diseases.

AB - In this report, we present data on a compound, ML168 (CID 2432214), which is able to protect cells from cytotoxicity induced by the expression of a large mutant poly-Q expansion Huntingtin (HTT) protein by inhibiting the activation of the intrinsic apoptotic pathway. This probe can be used in cellular assays and ex vivo experiments to study and inhibit the initiation of apoptosis induced by the expression of mutant, cytotoxic HTT protein. This probe will be of great interest to the scientific community that studies Huntington’s disease and other neurodegenerative diseases.

UR - http://www.ncbi.nlm.nih.gov/pubmed/21735602

UR - https://www.mendeley.com/catalogue/1c35a2e0-1210-37e6-9c2b-8ac4c93e9331/

M3 - Book

C2 - 21735602

BT - Identification of compounds which inhibit cytotoxicity associated with mutant Huntingtin protein expression

ER -

Identification of compounds which inhibit cytotoxicity associated with mutant Huntingtin protein expression

Abstract

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