Identification of compounds which inhibit cytotoxicity associated with mutant Huntingtin protein expression: In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information

Steve Titus, Natalie Elia, Noel Southall, Wei Zheng, Juan Jose Marugan, Marcy MacDonald

Research output: Book/ReportReportpeer-review

Abstract

In this report, we present data on a compound, ML168 (CID 2432214), which is able to protect cells from cytotoxicity induced by the expression of a large mutant poly-Q expansion Huntingtin (HTT) protein by inhibiting the activation of the intrinsic apoptotic pathway. This probe can be used in cellular assays and ex vivo experiments to study and inhibit the initiation of apoptosis induced by the expression of mutant, cytotoxic HTT protein. This probe will be of great interest to the scientific community that studies Huntington’s disease and other neurodegenerative diseases.
Original languageEnglish
Place of PublicationBethesda
Number of pages21
StatePublished - Mar 2010
Externally publishedYes

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