Identifying biological response pathways

Esti Yeger-Lotem (Inventor), Ernest Fraenkel (Inventor), David R. Karger (Inventor), Laura Riva (Inventor), Shao-Shan Carol Huang (Inventor)

Research output: Patent


A method for identifying a mechanism associated with a cellular response includes identifying molecules participating in the cellular response; accessing a database containing information characterizing molecular interactions; determining pathways connecting the identified molecules participating in the cellular response; and solving an optimization problem that includes determining a subset of the molecules and interactions having a minimum aggregate cost. The pathways include, nodes, each representing a molecule, and edges, each connecting a respective pair of nodes and representing an interaction between a respective pair of molecules represented by the respective pair of nodes. Nodes from a subset of nodes represent molecules identified as participating in the cellular response.
Original languageEnglish
Patent numberUS8612160
StatePublished - 2009


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