Identifying p53 Target Genes Using Hypomorphic Variants

Bibek Bhatta; Tomer Cooks

doi:10.1158/2159-8290.CD-23-0485

Identifying p53 Target Genes Using Hypomorphic Variants

Bibek Bhatta, Tomer Cooks

The Shraga Segal Department of Microbiology and Immunology

Research output: Contribution to journal › Editorial

Abstract

SUMMARY: The reduced tumor suppression activity of hypomorphic variants of the TP53 gene was used by Indeglia and colleagues to corroborate PADI4 as a p53 target. The study makes a noteworthy advancement in comprehending the downstream implications of TP53-PDI4, including potential predictions of survival and the efficacy of immunotherapy. See related article by Indeglia et al., p. 1696 (4).

Original language	English
Pages (from-to)	1518-1520
Number of pages	3
Journal	Cancer Discovery
Volume	13
Issue number	7
DOIs	https://doi.org/10.1158/2159-8290.CD-23-0485
State	Published - 7 Jul 2023

ASJC Scopus subject areas

Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1158/2159-8290.CD-23-0485

Cite this

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title = "Identifying p53 Target Genes Using Hypomorphic Variants",

abstract = "SUMMARY: The reduced tumor suppression activity of hypomorphic variants of the TP53 gene was used by Indeglia and colleagues to corroborate PADI4 as a p53 target. The study makes a noteworthy advancement in comprehending the downstream implications of TP53-PDI4, including potential predictions of survival and the efficacy of immunotherapy. See related article by Indeglia et al., p. 1696 (4).",

author = "Bibek Bhatta and Tomer Cooks",

note = "Publisher Copyright: {\textcopyright}2023 American Association for Cancer Research.",

year = "2023",

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AU - Bhatta, Bibek

AU - Cooks, Tomer

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N2 - SUMMARY: The reduced tumor suppression activity of hypomorphic variants of the TP53 gene was used by Indeglia and colleagues to corroborate PADI4 as a p53 target. The study makes a noteworthy advancement in comprehending the downstream implications of TP53-PDI4, including potential predictions of survival and the efficacy of immunotherapy. See related article by Indeglia et al., p. 1696 (4).

AB - SUMMARY: The reduced tumor suppression activity of hypomorphic variants of the TP53 gene was used by Indeglia and colleagues to corroborate PADI4 as a p53 target. The study makes a noteworthy advancement in comprehending the downstream implications of TP53-PDI4, including potential predictions of survival and the efficacy of immunotherapy. See related article by Indeglia et al., p. 1696 (4).

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SP - 1518

EP - 1520

JO - Cancer Discovery

JF - Cancer Discovery

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ER -

Identifying p53 Target Genes Using Hypomorphic Variants

Abstract

ASJC Scopus subject areas

UN SDGs

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