Identifying risk factors for placental abruption in subsequent pregnancy without a history of placental abruption

Adi Goldbart, Gali Pariente, Eyal Sheiner, Tamar Wainstock

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To identify first pregnancy risk factors for placental abruption in subsequent pregnancy. Methods: In a population-based nested case–control study, cases were defined as women with placental abruption in their second pregnancy, and controls as women without abruption. A total of 43 328 women were included in the study, 0.4% (n = 186) of second pregnancies had placental abruption. Multivariable logistic models were used to study the association between first pregnancy complications and placental abruption in subsequent pregnancy. Results: Having either small for gestational age, preterm delivery, pre-eclampsia or cesarean delivery during first pregnancy were independently associated with increased risk for placental abruption, and the risk was higher with any additional complication (age adjusted odds ratio [aOR] 2.00, 95% confidence interval [CI] 1.46–2.74; aOR 3.61, 95% CI 2.23–5.86; and aOR 3.86, 95% CI 1.56–9.56, for one, two, and three or more complications, respectively). Conclusion: First pregnancy may serve as a window of opportunity to identify women at risk for future placental abruption.

Original languageEnglish
Number of pages6
JournalInternational Journal of Gynecology and Obstetrics
Volume2022
DOIs
StatePublished - 9 Sep 2022

Keywords

  • abruption
  • cardiovascular morbidity
  • cesarean section
  • pre-eclampsia
  • preterm delivery
  • small for gestational age

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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