Idiotype Suppression in Immune Response of BALB/c Mice to α-1,3-Dextran by Antiidiotypic Antibody

Nirmala Bhoopalam, Naomi Meyerstein, Paul Heller

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The two mouse myeloma globulins, MOPC-104E IgM and J558 IgA, have antibody specificity to α-1,3-dextran and represent two idiotypes of antidextran antibodies. The results of the reported experiments indicate that idiotype suppression could be achieved by prior immunization of BALB/c mice with either 104E IgM or J558 IgA. After this immunization antibodies to dextran were only of the other idiotype. The absence of cross-reactivity strongly suggests that the idiotypes of antidextran antibodies are directed against different epitopic groups on the antigen.

Original languageEnglish
Pages (from-to)430-434
Number of pages5
JournalExperimental Biology and Medicine
Volume161
Issue number3
DOIs
StatePublished - 1 Jan 1979
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology (all)

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