IL-12 receptor 1β deficiency with features of autoimmunity and photosensitivity

Galina Ling, Eduard Ling, Arnon Broides, Hagit Poran Feldman, Jacov Levy, Ben Zion Garty, Amit Nahum

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Primary immunodeficiences are often accompanied by autoimmune phenomena. IL-12 receptor deficiency is a well characterized primary immunodeficiency that leads to propensity to intracellular infections mainly with mycobacteria and Salmonella. We report on two patients with IL-12 receptor β1 deficiency that presented with autoimmune manifestations and photosensitivity dermatitis and describe possible pathogenetic mechanisms leading to development of clinically significant autoimmune phenomena.

Original languageEnglish
Pages (from-to)143-146
Number of pages4
Issue number3
StatePublished - 2 Apr 2016
Externally publishedYes


  • Interleukin-12 receptor deficiency
  • SLE
  • immunoregulation
  • photosensitivity


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