IL-12 receptor 1β deficiency with features of autoimmunity and photosensitivity

Galina Ling; Eduard Ling; Arnon Broides; Hagit Poran Feldman; Jacov Levy; Ben Zion Garty; Amit Nahum

doi:10.3109/08916934.2015.1134513

IL-12 receptor 1β deficiency with features of autoimmunity and photosensitivity

Galina Ling, Eduard Ling, Arnon Broides, Hagit Poran Feldman, Jacov Levy, Ben Zion Garty, Amit Nahum

Medical School for International Health

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Primary immunodeficiences are often accompanied by autoimmune phenomena. IL-12 receptor deficiency is a well characterized primary immunodeficiency that leads to propensity to intracellular infections mainly with mycobacteria and Salmonella. We report on two patients with IL-12 receptor β1 deficiency that presented with autoimmune manifestations and photosensitivity dermatitis and describe possible pathogenetic mechanisms leading to development of clinically significant autoimmune phenomena.

Original language	English
Pages (from-to)	143-146
Number of pages	4
Journal	Autoimmunity
Volume	49
Issue number	3
DOIs	https://doi.org/10.3109/08916934.2015.1134513
State	Published - 2 Apr 2016

Keywords

Interleukin-12 receptor deficiency
SLE
immunoregulation
photosensitivity

ASJC Scopus subject areas

Immunology and Allergy
Immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3109/08916934.2015.1134513

Cite this

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title = "IL-12 receptor 1β deficiency with features of autoimmunity and photosensitivity",

abstract = "Primary immunodeficiences are often accompanied by autoimmune phenomena. IL-12 receptor deficiency is a well characterized primary immunodeficiency that leads to propensity to intracellular infections mainly with mycobacteria and Salmonella. We report on two patients with IL-12 receptor β1 deficiency that presented with autoimmune manifestations and photosensitivity dermatitis and describe possible pathogenetic mechanisms leading to development of clinically significant autoimmune phenomena.",

keywords = "Interleukin-12 receptor deficiency, SLE, immunoregulation, photosensitivity",

author = "Galina Ling and Eduard Ling and Arnon Broides and {Poran Feldman}, Hagit and Jacov Levy and Garty, {Ben Zion} and Amit Nahum",

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T1 - IL-12 receptor 1β deficiency with features of autoimmunity and photosensitivity

AU - Ling, Galina

AU - Ling, Eduard

AU - Broides, Arnon

AU - Poran Feldman, Hagit

AU - Levy, Jacov

AU - Garty, Ben Zion

AU - Nahum, Amit

PY - 2016/4/2

Y1 - 2016/4/2

N2 - Primary immunodeficiences are often accompanied by autoimmune phenomena. IL-12 receptor deficiency is a well characterized primary immunodeficiency that leads to propensity to intracellular infections mainly with mycobacteria and Salmonella. We report on two patients with IL-12 receptor β1 deficiency that presented with autoimmune manifestations and photosensitivity dermatitis and describe possible pathogenetic mechanisms leading to development of clinically significant autoimmune phenomena.

AB - Primary immunodeficiences are often accompanied by autoimmune phenomena. IL-12 receptor deficiency is a well characterized primary immunodeficiency that leads to propensity to intracellular infections mainly with mycobacteria and Salmonella. We report on two patients with IL-12 receptor β1 deficiency that presented with autoimmune manifestations and photosensitivity dermatitis and describe possible pathogenetic mechanisms leading to development of clinically significant autoimmune phenomena.

KW - Interleukin-12 receptor deficiency

KW - SLE

KW - immunoregulation

KW - photosensitivity

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JO - Autoimmunity

JF - Autoimmunity

IS - 3

ER -

IL-12 receptor 1β deficiency with features of autoimmunity and photosensitivity

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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