TY - JOUR
T1 - ImmGen at 15
AU - The Immunological Genome Project Consortium
AU - Aguilar, Stephanie Vargas
AU - Aguilar, Oscar
AU - Allan, Rhys
AU - Amir, El Ad David
AU - Angeli, Veronique
AU - Artyomov, Maxim N.
AU - Asinovski, Natasha
AU - Astarita, Jilian
AU - Austen, K. Frank
AU - Bajpai, Geetika
AU - Barrett, Nora
AU - Baysoy, Alev
AU - Benoist, Christophe
AU - Bellemare-Pelletier, Angelique
AU - Berg, Brad
AU - Best, Adam
AU - Bezman, Natalie
AU - Blair, David
AU - Blander, Julie M.
AU - Bogunovic, Milena
AU - Brennan, Patrick
AU - Brenner, Michael
AU - Brown, Brian
AU - Buechler, Matthew
AU - Buenrostro, Jason
AU - Casanova, Maria Acebes
AU - Choi, Kyunghee
AU - Chow, Andrew
AU - Chudnovskiy, Aleksey
AU - Cipoletta, Daniela
AU - Cohen, Nadia
AU - Collins, James J.
AU - Colonna, Marco
AU - Cook, Alison
AU - Costello, James
AU - Cremasco, Viviana
AU - Crowl, Ty
AU - Crozat, Karine
AU - Cruse, Richard
AU - D’Angelo, June
AU - Dalod, Marc
AU - Davis, Scott
AU - Demiralp, Cagatay
AU - Deng, Tianda
AU - Desai, Jigar V.
AU - Desland, Fiona
AU - Dhainaut, Maxime
AU - Gal-Oz, Shani
AU - Gazit, Roi
AU - Shay, Tal
N1 - Funding Information:
ImmGen was made possible by its sponsors and supporters, foremost the NIH NIAID, whose grant (R24-AI072073) unflinchingly supported the enterprise, but also by companies in the immunogenomics arena (eBioscience, BioLegend and Qiagen) who understood the goals and helped with collaborative participation in experimental design and discounted reagents. We thank the profiling facilities (Expression Analysis, Broad BTL and Genomics Platforms) for their professionalism and dedication in data generation.
PY - 2020/7/1
Y1 - 2020/7/1
N2 - The Immunological Genome Project (ImmGen) is a collaborative group of immunology and computational biology laboratories that perform a thorough dissection of gene expression and its regulation in the immune system of the mouse. This activity first centered on mRNA expression and then expanded to microRNA (miRNA), chromatin structure, nuclear organization and protein–RNA relationships. Shared protocols, data generation and QC pipelines have yielded data that can be directly compared from >250 stem, lymphoid and myeloid cell types, at baseline or under challenge. The group develops and applies computational tools to decipher regulatory connections and transcriptional control. From its inception, data generated by ImmGen were meant to be a public resource, and they can be accessed through dedicated web and smartphone platforms that use interactive graphic displays that make the results intuitive to users.
AB - The Immunological Genome Project (ImmGen) is a collaborative group of immunology and computational biology laboratories that perform a thorough dissection of gene expression and its regulation in the immune system of the mouse. This activity first centered on mRNA expression and then expanded to microRNA (miRNA), chromatin structure, nuclear organization and protein–RNA relationships. Shared protocols, data generation and QC pipelines have yielded data that can be directly compared from >250 stem, lymphoid and myeloid cell types, at baseline or under challenge. The group develops and applies computational tools to decipher regulatory connections and transcriptional control. From its inception, data generated by ImmGen were meant to be a public resource, and they can be accessed through dedicated web and smartphone platforms that use interactive graphic displays that make the results intuitive to users.
UR - http://www.scopus.com/inward/record.url?scp=85086781292&partnerID=8YFLogxK
U2 - 10.1038/s41590-020-0687-4
DO - 10.1038/s41590-020-0687-4
M3 - Comment/debate
C2 - 32577013
AN - SCOPUS:85086781292
SN - 1529-2908
VL - 21
SP - 700
EP - 703
JO - Nature Immunology
JF - Nature Immunology
IS - 7
ER -