TY - JOUR
T1 - Immune activation is a dominant factor in the pathogenesis of African AIDS
AU - Bentwich, Zvi
AU - Kalinkovich, Alexander
AU - Weisman, Ziva
N1 - Funding Information:
V7eg r~~tefull>kn o\\.ledgeY ehuda Barbut for help with graphics. R. Ben-.\ri Institute of Clinical Immunology is supported bv grants from the ICRF (New York, USA) and the Israeli Ministry of Hralrh.
PY - 1995/1/1
Y1 - 1995/1/1
N2 - The AIDS epidemic in Africa is very different from the epidemic in the West. As suggested here by Zvi Bentwich, Alexander Kalinkovich and Ziva Weisman, this appears to be primarily a consequence of the over-activation of the immune system in the African population, owing to the extremely high prevalence of infections, particularly helminthic, in Africa. Such activation shifts the cytokine balance towards a T helper 0/2 (Th0/2)-type response, which makes the host more susceptible to infection with human immunodeficiency virus (HIV) and less able to cope with it.
AB - The AIDS epidemic in Africa is very different from the epidemic in the West. As suggested here by Zvi Bentwich, Alexander Kalinkovich and Ziva Weisman, this appears to be primarily a consequence of the over-activation of the immune system in the African population, owing to the extremely high prevalence of infections, particularly helminthic, in Africa. Such activation shifts the cytokine balance towards a T helper 0/2 (Th0/2)-type response, which makes the host more susceptible to infection with human immunodeficiency virus (HIV) and less able to cope with it.
UR - http://www.scopus.com/inward/record.url?scp=0028904083&partnerID=8YFLogxK
U2 - 10.1016/0167-5699(95)80119-7
DO - 10.1016/0167-5699(95)80119-7
M3 - Article
C2 - 7734046
AN - SCOPUS:0028904083
SN - 0167-5699
VL - 16
SP - 187
EP - 191
JO - Immunology Today
JF - Immunology Today
IS - 4
ER -
