Immune impairments and antibodies to HTL VIII/LAV in asymptomatic male homosexuals in Israel: Relevance to the risk of acquired immune deficiency syndrome (AIDS)

Zvi Bentwich; Carl Saxinger; Zvi Ben-Ishay; Rimona Burstein; Yitshal Berner; Marit Pecht; Nathan Trainin; Stanley Levin; Zeev T. Handzel

doi:10.1007/BF00917015

Immune impairments and antibodies to HTL VIII/LAV in asymptomatic male homosexuals in Israel: Relevance to the risk of acquired immune deficiency syndrome (AIDS)

Zvi Bentwich, Carl Saxinger, Zvi Ben-Ishay, Rimona Burstein, Yitshal Berner, Marit Pecht, Nathan Trainin, Stanley Levin, Zeev T. Handzel

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5 Scopus citations

Abstract

We have studied 288 Israeli asymptomatic male homosexuals (MHS) to determine the prevalence of antibodies to HTLVI and HTLVIII and their correlation with impairments of the immune system and serum interferon (IFN). Seropositivity for HTLVI, HTLVIII, or both was found in 1.4, 8.3, and 0%, respectively. Significant decreases in the total peripheral T cells, T_H cells, and T_H/T_S ratio as well as elevated αIFN serum levels were found in the MHS group in comparison with normal controls. Although no difference in the prevalence of either immune derangements or elevated serum IFN was observed between HTLVIII/LAV-seropositive and HTLVIII/LAV-seronegative MHS, the decreases in total T cells, T_H cells, and T_H/T_S ratios were significantly greater in the seropositive MHS. These results indicate that (a) immune impairments and IFN system activation occur commonly in homosexuals, precede their exposure to HTLVIII/LAV, and probably reflect this group's increased risk for AIDS and (b) HTLVIII/LAV infection of MHS aggravates further their preexisting immune impairments.

Original language	English
Pages (from-to)	376-380
Number of pages	5
Journal	Journal of Clinical Immunology
Volume	7
Issue number	5
DOIs	https://doi.org/10.1007/BF00917015
State	Published - 1 Sep 1987
Externally published	Yes

Keywords

Acquired immune deficiency syndrome (AIDS)
cofactors
male homosexuals
risk groups

ASJC Scopus subject areas

Immunology and Allergy
Immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/BF00917015

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Bentwich, Z., Saxinger, C., Ben-Ishay, Z., Burstein, R., Berner, Y., Pecht, M., Trainin, N., Levin, S., & Handzel, Z. T. (1987). Immune impairments and antibodies to HTL VIII/LAV in asymptomatic male homosexuals in Israel: Relevance to the risk of acquired immune deficiency syndrome (AIDS). Journal of Clinical Immunology, 7(5), 376-380. https://doi.org/10.1007/BF00917015

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title = "Immune impairments and antibodies to HTL VIII/LAV in asymptomatic male homosexuals in Israel: Relevance to the risk of acquired immune deficiency syndrome (AIDS)",

abstract = "We have studied 288 Israeli asymptomatic male homosexuals (MHS) to determine the prevalence of antibodies to HTLVI and HTLVIII and their correlation with impairments of the immune system and serum interferon (IFN). Seropositivity for HTLVI, HTLVIII, or both was found in 1.4, 8.3, and 0%, respectively. Significant decreases in the total peripheral T cells, TH cells, and TH/TS ratio as well as elevated αIFN serum levels were found in the MHS group in comparison with normal controls. Although no difference in the prevalence of either immune derangements or elevated serum IFN was observed between HTLVIII/LAV-seropositive and HTLVIII/LAV-seronegative MHS, the decreases in total T cells, TH cells, and TH/TS ratios were significantly greater in the seropositive MHS. These results indicate that (a) immune impairments and IFN system activation occur commonly in homosexuals, precede their exposure to HTLVIII/LAV, and probably reflect this group's increased risk for AIDS and (b) HTLVIII/LAV infection of MHS aggravates further their preexisting immune impairments.",

keywords = "Acquired immune deficiency syndrome (AIDS), cofactors, male homosexuals, risk groups",

author = "Zvi Bentwich and Carl Saxinger and Zvi Ben-Ishay and Rimona Burstein and Yitshal Berner and Marit Pecht and Nathan Trainin and Stanley Levin and Handzel, {Zeev T.}",

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Bentwich, Z, Saxinger, C, Ben-Ishay, Z, Burstein, R, Berner, Y, Pecht, M, Trainin, N, Levin, S & Handzel, ZT 1987, 'Immune impairments and antibodies to HTL VIII/LAV in asymptomatic male homosexuals in Israel: Relevance to the risk of acquired immune deficiency syndrome (AIDS)', Journal of Clinical Immunology, vol. 7, no. 5, pp. 376-380. https://doi.org/10.1007/BF00917015

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AU - Bentwich, Zvi

AU - Saxinger, Carl

AU - Ben-Ishay, Zvi

AU - Burstein, Rimona

AU - Berner, Yitshal

AU - Pecht, Marit

AU - Trainin, Nathan

AU - Levin, Stanley

AU - Handzel, Zeev T.

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N2 - We have studied 288 Israeli asymptomatic male homosexuals (MHS) to determine the prevalence of antibodies to HTLVI and HTLVIII and their correlation with impairments of the immune system and serum interferon (IFN). Seropositivity for HTLVI, HTLVIII, or both was found in 1.4, 8.3, and 0%, respectively. Significant decreases in the total peripheral T cells, TH cells, and TH/TS ratio as well as elevated αIFN serum levels were found in the MHS group in comparison with normal controls. Although no difference in the prevalence of either immune derangements or elevated serum IFN was observed between HTLVIII/LAV-seropositive and HTLVIII/LAV-seronegative MHS, the decreases in total T cells, TH cells, and TH/TS ratios were significantly greater in the seropositive MHS. These results indicate that (a) immune impairments and IFN system activation occur commonly in homosexuals, precede their exposure to HTLVIII/LAV, and probably reflect this group's increased risk for AIDS and (b) HTLVIII/LAV infection of MHS aggravates further their preexisting immune impairments.

AB - We have studied 288 Israeli asymptomatic male homosexuals (MHS) to determine the prevalence of antibodies to HTLVI and HTLVIII and their correlation with impairments of the immune system and serum interferon (IFN). Seropositivity for HTLVI, HTLVIII, or both was found in 1.4, 8.3, and 0%, respectively. Significant decreases in the total peripheral T cells, TH cells, and TH/TS ratio as well as elevated αIFN serum levels were found in the MHS group in comparison with normal controls. Although no difference in the prevalence of either immune derangements or elevated serum IFN was observed between HTLVIII/LAV-seropositive and HTLVIII/LAV-seronegative MHS, the decreases in total T cells, TH cells, and TH/TS ratios were significantly greater in the seropositive MHS. These results indicate that (a) immune impairments and IFN system activation occur commonly in homosexuals, precede their exposure to HTLVIII/LAV, and probably reflect this group's increased risk for AIDS and (b) HTLVIII/LAV infection of MHS aggravates further their preexisting immune impairments.

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KW - risk groups

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Immune impairments and antibodies to HTL VIII/LAV in asymptomatic male homosexuals in Israel: Relevance to the risk of acquired immune deficiency syndrome (AIDS)

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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