Immune investigations and therapy in patients with advanced lung cancer

Tamar Mekori; Ruth Segal; Arie Bartal; Yoram Cohen; Eliezer Robinson

doi:10.1007/BF00205474

Immune investigations and therapy in patients with advanced lung cancer

Tamar Mekori, Ruth Segal, Arie Bartal, Yoram Cohen, Eliezer Robinson

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Fifty-one patients with advanced lung cancer were divided at random into two groups before conventional therapy was started. One group of 29 patients was treated with a Methanol Extraction Residue of Bacillus Calmette-Guérin (MER) administered intradermally in addition to the conventional radiotherapy and/or chemotherapy treatment. These patients will be referred to as the group. The other group of 22 patients was treated by the conventional method only and is designated the RC group. The general immunological status of these two groups of patients was evaluated once a month by the following in vivo and in vitro tests: Skin tests to five memory antigens: PPD, SK/SD, Candidin, Trichophytin, and mixed bacteria; lymphocyte stimulation in response to the mitogen PHA and to PPD and Candidin. In addition, E- and EAC-rosettes were determined in peripheral blood. The results show that after some of the treatments increased formation of E rosettes, improved in skin reactivity, and higher stimulation indices of cultured lymphocytes were found in the RCM group than in the RC group.

Original language	English
Pages (from-to)	251-255
Number of pages	5
Journal	Cancer Immunology, Immunotherapy
Volume	7
Issue number	4
DOIs	https://doi.org/10.1007/BF00205474
State	Published - 1 Jan 1980
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology
Cancer Research

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/BF00205474

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title = "Immune investigations and therapy in patients with advanced lung cancer",

abstract = "Fifty-one patients with advanced lung cancer were divided at random into two groups before conventional therapy was started. One group of 29 patients was treated with a Methanol Extraction Residue of Bacillus Calmette-Gu{\'e}rin (MER) administered intradermally in addition to the conventional radiotherapy and/or chemotherapy treatment. These patients will be referred to as the group. The other group of 22 patients was treated by the conventional method only and is designated the RC group. The general immunological status of these two groups of patients was evaluated once a month by the following in vivo and in vitro tests: Skin tests to five memory antigens: PPD, SK/SD, Candidin, Trichophytin, and mixed bacteria; lymphocyte stimulation in response to the mitogen PHA and to PPD and Candidin. In addition, E- and EAC-rosettes were determined in peripheral blood. The results show that after some of the treatments increased formation of E rosettes, improved in skin reactivity, and higher stimulation indices of cultured lymphocytes were found in the RCM group than in the RC group.",

author = "Tamar Mekori and Ruth Segal and Arie Bartal and Yoram Cohen and Eliezer Robinson",

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doi = "10.1007/BF00205474",

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AU - Mekori, Tamar

AU - Segal, Ruth

AU - Bartal, Arie

AU - Cohen, Yoram

AU - Robinson, Eliezer

PY - 1980/1/1

Y1 - 1980/1/1

N2 - Fifty-one patients with advanced lung cancer were divided at random into two groups before conventional therapy was started. One group of 29 patients was treated with a Methanol Extraction Residue of Bacillus Calmette-Guérin (MER) administered intradermally in addition to the conventional radiotherapy and/or chemotherapy treatment. These patients will be referred to as the group. The other group of 22 patients was treated by the conventional method only and is designated the RC group. The general immunological status of these two groups of patients was evaluated once a month by the following in vivo and in vitro tests: Skin tests to five memory antigens: PPD, SK/SD, Candidin, Trichophytin, and mixed bacteria; lymphocyte stimulation in response to the mitogen PHA and to PPD and Candidin. In addition, E- and EAC-rosettes were determined in peripheral blood. The results show that after some of the treatments increased formation of E rosettes, improved in skin reactivity, and higher stimulation indices of cultured lymphocytes were found in the RCM group than in the RC group.

AB - Fifty-one patients with advanced lung cancer were divided at random into two groups before conventional therapy was started. One group of 29 patients was treated with a Methanol Extraction Residue of Bacillus Calmette-Guérin (MER) administered intradermally in addition to the conventional radiotherapy and/or chemotherapy treatment. These patients will be referred to as the group. The other group of 22 patients was treated by the conventional method only and is designated the RC group. The general immunological status of these two groups of patients was evaluated once a month by the following in vivo and in vitro tests: Skin tests to five memory antigens: PPD, SK/SD, Candidin, Trichophytin, and mixed bacteria; lymphocyte stimulation in response to the mitogen PHA and to PPD and Candidin. In addition, E- and EAC-rosettes were determined in peripheral blood. The results show that after some of the treatments increased formation of E rosettes, improved in skin reactivity, and higher stimulation indices of cultured lymphocytes were found in the RCM group than in the RC group.

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ER -

Immune investigations and therapy in patients with advanced lung cancer

Abstract

ASJC Scopus subject areas

UN SDGs

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