Immune investigations and therapy in patients with advanced lung cancer

Tamar Mekori, Ruth Segal, Arie Bartal, Yoram Cohen, Eliezer Robinson

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Fifty-one patients with advanced lung cancer were divided at random into two groups before conventional therapy was started. One group of 29 patients was treated with a Methanol Extraction Residue of Bacillus Calmette-Guérin (MER) administered intradermally in addition to the conventional radiotherapy and/or chemotherapy treatment. These patients will be referred to as the group. The other group of 22 patients was treated by the conventional method only and is designated the RC group. The general immunological status of these two groups of patients was evaluated once a month by the following in vivo and in vitro tests: Skin tests to five memory antigens: PPD, SK/SD, Candidin, Trichophytin, and mixed bacteria; lymphocyte stimulation in response to the mitogen PHA and to PPD and Candidin. In addition, E- and EAC-rosettes were determined in peripheral blood. The results show that after some of the treatments increased formation of E rosettes, improved in skin reactivity, and higher stimulation indices of cultured lymphocytes were found in the RCM group than in the RC group.

Original languageEnglish
Pages (from-to)251-255
Number of pages5
JournalCancer Immunology, Immunotherapy
Issue number4
StatePublished - 1 Jan 1980
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology
  • Cancer Research


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