The immunological status during aging was assessed by measuring the antibody Besponse of the long-lived (C3H/eb × C5J7B1/6J)F1 mice to various antigens in vivo and in vitro. In vivo, a decrease in antibody production to DNP and NIP haptenic determinants coupled on to BGG, as well as the response to SRBC, was observed. The decline was more pronounced in the IgG as compared to IgM antibodies. The results were recorded when various parameters such as antigen dose and kinetics of the response, were considered. Reduction of the antibody response was also noted when PVP was employed as immunogen. helper and the B cell compartments.
ASJC Scopus subject areas
- Developmental Biology