Immune tolerance as a strategy for treatment of atherosclerosis

Ora Shovman, Gisele Zandman-Goddard, Yaniv Sherer, Boris Gilburd, Yehuda Shoenfeld

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Recently, considerable data have accumulated concerning the role of the immune system in atherosclerosis (AS). Several immunomodulating strategies are being evaluated that might influence the process of AS including immunosuppressive therapy, immunization (vaccination) and induction of immune tolerance. This article reviews experimental studies using the induction of immune tolerance for the suppression of respective immune responses in animal models of AS. Induction of neonatal tolerance or mucosal tolerance using autoantigens involved in atherogenesis, such as heat shock protein-65 or beta2-glycoprotein I, could modify the course of AS in animal models. These observations are of considerable interest and need further evaluation in humans.

Original languageEnglish
Pages (from-to)207-211
Number of pages5
JournalDrug Discovery Today: Therapeutic Strategies
Issue number3
StatePublished - 31 Oct 2005
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery


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