Abstract
Recently, considerable data have accumulated concerning the role of the immune system in atherosclerosis (AS). Several immunomodulating strategies are being evaluated that might influence the process of AS including immunosuppressive therapy, immunization (vaccination) and induction of immune tolerance. This article reviews experimental studies using the induction of immune tolerance for the suppression of respective immune responses in animal models of AS. Induction of neonatal tolerance or mucosal tolerance using autoantigens involved in atherogenesis, such as heat shock protein-65 or beta2-glycoprotein I, could modify the course of AS in animal models. These observations are of considerable interest and need further evaluation in humans.
Original language | English |
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Pages (from-to) | 207-211 |
Number of pages | 5 |
Journal | Drug Discovery Today: Therapeutic Strategies |
Volume | 2 |
Issue number | 3 |
DOIs | |
State | Published - 31 Oct 2005 |
Externally published | Yes |
ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology
- Drug Discovery