Immunogenicity of haemophilus influenzae type b tetanus toxoid conjugate vaccinein young infants

David P. Greenberg, Constance M. Vadheim, Susan Partridge, Swei Ju Chang, Chung Yin Chiu, Joel I. Ward, S. Michael Marcy, Bradley Ackerson, C. Balakrishnan, Terry Cashmore, James Gates, James Heywood, Waldo Luciano, John Miller, Catalina Preskill, Evan Steinberg, Michael Sultan, Mariano Tan, Victor Wong

Research output: Contribution to journalArticlepeer-review

56 Scopus citations


In a prospective, randomized, double-blind efficacy trial, the immunogenicity of 10 lots of Haemophilus injluenzae type b capsular polysaccharide-tetanus toxoid conjugate vaccine (PRP-T) was evaluated. More than 10, 000 infants received PRP-T or hepatitis Bvaccine at about 2, 4, and 6 months of age along with other childhood vaccines. In a subset of infants, geometric mean concentrations of total anticapsular antibody were 0.08, 0.79, and 5.29 μg/mL after the first, second, and third doses, respectively. Four lots of reconstituted lyophilized PRP-T vaccine were significantly more immunogenic than 6 lots of aqueous vaccine (P =.03). In a stepwise regression model, the most important additional factors affecting anticapsular antibody concentrations were the time between the third dose and the blood draw, race, and breast-feeding status at 6 months of age. Immune responses to diphtheria and tetanus toxoids were not significantly different for infants given PRP-T or hepatitis Bvaccines along with diphtheria-tetanus toxoid-pertussis vaccine.

Original languageEnglish
Pages (from-to)76-81
Number of pages6
JournalJournal of Infectious Diseases
Issue number1
StatePublished - 1 Jan 1994
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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