TY - JOUR
T1 - Immunogenicity of haemophilus influenzae type b tetanus toxoid conjugate vaccinein young infants
AU - Greenberg, David P.
AU - Vadheim, Constance M.
AU - Partridge, Susan
AU - Chang, Swei Ju
AU - Chiu, Chung Yin
AU - Ward, Joel I.
AU - Marcy, S. Michael
AU - Ackerson, Bradley
AU - Balakrishnan, C.
AU - Cashmore, Terry
AU - Gates, James
AU - Heywood, James
AU - Luciano, Waldo
AU - Miller, John
AU - Preskill, Catalina
AU - Steinberg, Evan
AU - Sultan, Michael
AU - Tan, Mariano
AU - Wong, Victor
PY - 1994/1/1
Y1 - 1994/1/1
N2 - In a prospective, randomized, double-blind efficacy trial, the immunogenicity of 10 lots of Haemophilus injluenzae type b capsular polysaccharide-tetanus toxoid conjugate vaccine (PRP-T) was evaluated. More than 10, 000 infants received PRP-T or hepatitis Bvaccine at about 2, 4, and 6 months of age along with other childhood vaccines. In a subset of infants, geometric mean concentrations of total anticapsular antibody were 0.08, 0.79, and 5.29 μg/mL after the first, second, and third doses, respectively. Four lots of reconstituted lyophilized PRP-T vaccine were significantly more immunogenic than 6 lots of aqueous vaccine (P =.03). In a stepwise regression model, the most important additional factors affecting anticapsular antibody concentrations were the time between the third dose and the blood draw, race, and breast-feeding status at 6 months of age. Immune responses to diphtheria and tetanus toxoids were not significantly different for infants given PRP-T or hepatitis Bvaccines along with diphtheria-tetanus toxoid-pertussis vaccine.
AB - In a prospective, randomized, double-blind efficacy trial, the immunogenicity of 10 lots of Haemophilus injluenzae type b capsular polysaccharide-tetanus toxoid conjugate vaccine (PRP-T) was evaluated. More than 10, 000 infants received PRP-T or hepatitis Bvaccine at about 2, 4, and 6 months of age along with other childhood vaccines. In a subset of infants, geometric mean concentrations of total anticapsular antibody were 0.08, 0.79, and 5.29 μg/mL after the first, second, and third doses, respectively. Four lots of reconstituted lyophilized PRP-T vaccine were significantly more immunogenic than 6 lots of aqueous vaccine (P =.03). In a stepwise regression model, the most important additional factors affecting anticapsular antibody concentrations were the time between the third dose and the blood draw, race, and breast-feeding status at 6 months of age. Immune responses to diphtheria and tetanus toxoids were not significantly different for infants given PRP-T or hepatitis Bvaccines along with diphtheria-tetanus toxoid-pertussis vaccine.
UR - http://www.scopus.com/inward/record.url?scp=0028304465&partnerID=8YFLogxK
U2 - 10.1093/infdis/170.1.76
DO - 10.1093/infdis/170.1.76
M3 - Article
AN - SCOPUS:0028304465
SN - 0022-1899
VL - 170
SP - 76
EP - 81
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 1
ER -
