TY - JOUR
T1 - Immunohistochemical expression of platelet growth factor and vascular endothelial growth factor in patients with melanoma with and without redness (Brenner sign)
AU - Mashiah, Jacob
AU - Wohl, Yonit
AU - Barnea, Yoav
AU - Schneebaum, Shlomo
AU - Gat, Andrea
AU - Misonzhnik-Bedny, Faina
AU - Brenner, Sarah
PY - 2007/8/1
Y1 - 2007/8/1
N2 - Objective: To assess whether an erythematous eruption in the vicinity of or distant from a melanoma lesion might be related to the vascular endothelial growth factor, the platelet-derived endothelial cell growth factor, or both. Methods: Biopsy specimens from 13 patients with primary melanoma, 6 of whom had erythematous eruptions and 7 who did not, were studied by immunohistochemistry for the expression of vascular endothelial growth factor and platelet-derived endothelial cell growth factor. Results: Vascular endothelial growth factor was positive in 3 of 6 patients (50%) with melanoma and redness (Brenner sign) and in 4 of 7 patients (57%) with melanoma without redness. Platelet-derived endothelial cell growth factor was positive in all 6 patients (100%) with melanoma and redness and in 4 of 7 patients (57%) with melanoma without redness. Conclusion: Platelet-derived endothelial cell growth factor may have a part in the pathogenesis of the redness observed in patients with melanoma, called Brenner sign, by affecting vasculature function.
AB - Objective: To assess whether an erythematous eruption in the vicinity of or distant from a melanoma lesion might be related to the vascular endothelial growth factor, the platelet-derived endothelial cell growth factor, or both. Methods: Biopsy specimens from 13 patients with primary melanoma, 6 of whom had erythematous eruptions and 7 who did not, were studied by immunohistochemistry for the expression of vascular endothelial growth factor and platelet-derived endothelial cell growth factor. Results: Vascular endothelial growth factor was positive in 3 of 6 patients (50%) with melanoma and redness (Brenner sign) and in 4 of 7 patients (57%) with melanoma without redness. Platelet-derived endothelial cell growth factor was positive in all 6 patients (100%) with melanoma and redness and in 4 of 7 patients (57%) with melanoma without redness. Conclusion: Platelet-derived endothelial cell growth factor may have a part in the pathogenesis of the redness observed in patients with melanoma, called Brenner sign, by affecting vasculature function.
UR - http://www.scopus.com/inward/record.url?scp=34548063555&partnerID=8YFLogxK
U2 - 10.1001/archderm.143.8.1001
DO - 10.1001/archderm.143.8.1001
M3 - Article
AN - SCOPUS:34548063555
SN - 0003-987X
VL - 143
SP - 1001
EP - 1004
JO - Archives of Dermatology
JF - Archives of Dermatology
IS - 8
ER -