Immunohistochemical Study of Hace1 in Wilms' Tumor and Breast Cancer Suggests a Pro-Tumorigenic Role for Its Nuclear Isoform

T Ng; F Zhang; J Mathers; B Rotblat; D Fink; V Friedrich; A Li; H Joensuu; P Sorensen

doi:10.1038/labinvest.2008.149

Immunohistochemical Study of Hace1 in Wilms' Tumor and Breast Cancer Suggests a Pro-Tumorigenic Role for Its Nuclear Isoform

T Ng
, F Zhang
, J Mathers
, B Rotblat
, D Fink
, V Friedrich
, A Li
, H Joensuu
, P Sorensen

Department of Life Sciences

Research output: Contribution to journal › Meeting Abstract

Abstract

Design: Using a mouse monoclonal antibody we developed, immunohistochemistry (IHC) was performed on ten WT cases along with matched normal kidney. We also performed Hace1 IHC on a tissue microarray (TMA) of 1378 interpretable breast cancer cases with associated prognostic data, including median follow-up time for non-relapsed patients of 9.5 years. Hace1 expression was scored separately for cytoplasmic and nuclear staining (0=negative; 1+=weak or <10% positive cells, 2+=strong >10% of cells, 3+=intense in >50% cells).

Original language	English
Pages (from-to)	341A-342A
Number of pages	2
Journal	Laboratory Investigation
Volume	89
Issue number	1s
DOIs	https://doi.org/10.1038/labinvest.2008.149
State	Published - Jan 2009

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10.1038/labinvest.2008.149

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@article{e17740ce41484b778271fc084ecf2e88,

title = "Immunohistochemical Study of Hace1 in Wilms' Tumor and Breast Cancer Suggests a Pro-Tumorigenic Role for Its Nuclear Isoform",

abstract = "Design: Using a mouse monoclonal antibody we developed, immunohistochemistry (IHC) was performed on ten WT cases along with matched normal kidney. We also performed Hace1 IHC on a tissue microarray (TMA) of 1378 interpretable breast cancer cases with associated prognostic data, including median follow-up time for non-relapsed patients of 9.5 years. Hace1 expression was scored separately for cytoplasmic and nuclear staining (0=negative; 1+=weak or <10\% positive cells, 2+=strong >10\% of cells, 3+=intense in >50\% cells).",

author = "T Ng and F Zhang and J Mathers and B Rotblat and D Fink and V Friedrich and A Li and H Joensuu and P Sorensen",

year = "2009",

month = jan,

doi = "10.1038/labinvest.2008.149",

language = "English",

volume = "89",

pages = "341A--342A",

journal = "Laboratory Investigation",

issn = "0023-6837",

publisher = "Elsevier B.V.",

number = "1s",

}

TY - JOUR

T1 - Immunohistochemical Study of Hace1 in Wilms' Tumor and Breast Cancer Suggests a Pro-Tumorigenic Role for Its Nuclear Isoform

AU - Ng, T

AU - Zhang, F

AU - Mathers, J

AU - Rotblat, B

AU - Fink, D

AU - Friedrich, V

AU - Li, A

AU - Joensuu, H

AU - Sorensen, P

PY - 2009/1

Y1 - 2009/1

N2 - Design: Using a mouse monoclonal antibody we developed, immunohistochemistry (IHC) was performed on ten WT cases along with matched normal kidney. We also performed Hace1 IHC on a tissue microarray (TMA) of 1378 interpretable breast cancer cases with associated prognostic data, including median follow-up time for non-relapsed patients of 9.5 years. Hace1 expression was scored separately for cytoplasmic and nuclear staining (0=negative; 1+=weak or <10% positive cells, 2+=strong >10% of cells, 3+=intense in >50% cells).

AB - Design: Using a mouse monoclonal antibody we developed, immunohistochemistry (IHC) was performed on ten WT cases along with matched normal kidney. We also performed Hace1 IHC on a tissue microarray (TMA) of 1378 interpretable breast cancer cases with associated prognostic data, including median follow-up time for non-relapsed patients of 9.5 years. Hace1 expression was scored separately for cytoplasmic and nuclear staining (0=negative; 1+=weak or <10% positive cells, 2+=strong >10% of cells, 3+=intense in >50% cells).

U2 - 10.1038/labinvest.2008.149

DO - 10.1038/labinvest.2008.149

M3 - Meeting Abstract

SN - 0023-6837

VL - 89

SP - 341A-342A

JO - Laboratory Investigation

JF - Laboratory Investigation

IS - 1s

ER -

Immunohistochemical Study of Hace1 in Wilms' Tumor and Breast Cancer Suggests a Pro-Tumorigenic Role for Its Nuclear Isoform

Abstract

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