TY - JOUR
T1 - Immunologic Studies in Darier's Disease
AU - Halevy, S.
AU - Weltfriend, S.
AU - Pick, A. I.
AU - Weiss, H.
AU - Duczyminer‐Kahana, M.
AU - Sandbank, M.
PY - 1988/1/1
Y1 - 1988/1/1
N2 - ABSTRACT: Humoral and cellular immunity were evaluated in 10 patients with Darier's disease. The mean levels of serum immunoglobulins, serum complement, peripheral macro‐phages, and peripheral B and T lymphocytes were within normal limits. Secretory IgA was present in all patients studied. Skin tests for delayed hypersensitivity revealed complete anergy in one of the eight patients tested. Lymphocyte transformation tests revealed statistically significant enhanced responsiveness to both PHA and ConA mitogens in several concentrations studied. These findings may suggest either the existence of alterations in immunoregulation of lymphocyte subpopulations in Darier's disease or may be limited to alterations in membrane functions of certain lymphocyte subpopulations which can be detected only in vitro. The role that such immunologic aberrations may play in the pathogenesis of Darier's disease is still obscure.
AB - ABSTRACT: Humoral and cellular immunity were evaluated in 10 patients with Darier's disease. The mean levels of serum immunoglobulins, serum complement, peripheral macro‐phages, and peripheral B and T lymphocytes were within normal limits. Secretory IgA was present in all patients studied. Skin tests for delayed hypersensitivity revealed complete anergy in one of the eight patients tested. Lymphocyte transformation tests revealed statistically significant enhanced responsiveness to both PHA and ConA mitogens in several concentrations studied. These findings may suggest either the existence of alterations in immunoregulation of lymphocyte subpopulations in Darier's disease or may be limited to alterations in membrane functions of certain lymphocyte subpopulations which can be detected only in vitro. The role that such immunologic aberrations may play in the pathogenesis of Darier's disease is still obscure.
UR - http://www.scopus.com/inward/record.url?scp=0023906449&partnerID=8YFLogxK
U2 - 10.1111/j.1365-4362.1988.tb01281.x
DO - 10.1111/j.1365-4362.1988.tb01281.x
M3 - Article
AN - SCOPUS:0023906449
SN - 0011-9059
VL - 27
SP - 101
EP - 105
JO - International Journal of Dermatology
JF - International Journal of Dermatology
IS - 2
ER -