Immunologic Studies in Darier's Disease

S. Halevy, S. Weltfriend, A. I. Pick, H. Weiss, M. Duczyminer‐Kahana, M. Sandbank

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


ABSTRACT: Humoral and cellular immunity were evaluated in 10 patients with Darier's disease. The mean levels of serum immunoglobulins, serum complement, peripheral macro‐phages, and peripheral B and T lymphocytes were within normal limits. Secretory IgA was present in all patients studied. Skin tests for delayed hypersensitivity revealed complete anergy in one of the eight patients tested. Lymphocyte transformation tests revealed statistically significant enhanced responsiveness to both PHA and ConA mitogens in several concentrations studied. These findings may suggest either the existence of alterations in immunoregulation of lymphocyte subpopulations in Darier's disease or may be limited to alterations in membrane functions of certain lymphocyte subpopulations which can be detected only in vitro. The role that such immunologic aberrations may play in the pathogenesis of Darier's disease is still obscure.

Original languageEnglish
Pages (from-to)101-105
Number of pages5
JournalInternational Journal of Dermatology
Issue number2
StatePublished - 1 Jan 1988
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology


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