Immunological destruction of herpes simplex virus I infected cells

Bracha Rager-Zisman, Barry R. Bloom

Research output: Contribution to journalArticlepeer-review

60 Scopus citations


THERE are clearly two levels at which the immune response may intervene to induce protection against viral infection. Neutralising antibodies effectively limit spread of free virus in many situations, thus preventing reinfection. In a number of viral diseases, however, it is often not possible to cure the infection by even high titres of neutralising antibodies1,2. In such situations, recovery from infection may require the intervention of a cell-mediated immune response directed at the infected cell. Selective impairment of the host's immunity, for example, by thymectomy or by antilymphocyte serum, markedly increased mortality of mice infected with ectromelia3, and herpes simplex4,5. Macrophage suppression has had a similar effect6. In these cases recovery could be conferred by transfer of immune lymphoid cells (ref. 7 and B.R-Z., and A. C. Allison, unpublished). But the nature of the cells involved, and the mechanisms by which they act remain problematic. Our experiments were undertaken to evaluate the contribution of various types of cells to immune reactivity to cells infected with herpes simplex virus I in vitro.

Original languageEnglish
Pages (from-to)542-543
Number of pages2
Issue number5475
StatePublished - 1 Dec 1974
Externally publishedYes

ASJC Scopus subject areas

  • General


Dive into the research topics of 'Immunological destruction of herpes simplex virus I infected cells'. Together they form a unique fingerprint.

Cite this