@article{d449a55dc93b4bd49c12693806c586f4,
title = "Immunological Genome Project and systems immunology",
abstract = "Immunological studies of single proteins in a single cell type have been complemented in recent years by larger studies, enabled by emerging high-throughput technologies. This trend has recently been exemplified by the discovery of gene networks controlling regulatory and effector αβ T cell subset development and human hematopoiesis. The Immunological Genome Project (ImmGen) aims to decipher the gene networks underpinning mouse hematopoiesis. The first phase, completed in 2012, profiled the transcriptome of 249 immune cell types. We discuss the utilities of the datasets in high-resolution mapping of the hematopoietic system. The immune transcriptome compendium has revealed unsuspected cell lineage relations and the network reconstruction has identified novel regulatory factors of hematopoiesis.",
keywords = "Hematopoiesis, Systems immunology, Transcriptional regulation",
author = "Tal Shay and Joonsoo Kang",
note = "Funding Information: We thank the ImmGen laboratories, L. Lanier, S. Itzkovitz, A. Elbaz, and S. Tal for discussion, L. Gaffney for help with the figures, and eBioscience, Affymetrix, and Expression Analysis for support of the ImmGen Project. Supported by NIH CA100382, AI101301 to J.K., and AI072073 to ImmGen. The ImmGen Project Consortium consists of: Paul Monach, Susan A. Shinton, Richard R. Hardy, Radu Jianu, David Koller, Jim Collins, Roi Gazit, Brian S. Garrison, Derrick J. Rossi, Kavitha Narayan, Katelyn Sylvia, Joonsoo Kang, Anne Fletcher, Kutlu Elpek, Angelique Bellemare-Pelletier, Deepali Malhotra, Shannon Turley, Adam J. Best, Jamie Knell, Ananda Goldrath, Vladimir Jojic, Daphne Koller, Tal Shay, Aviv Regev, Nadia Cohen, Patrick Brennan, Michael Brenner, Taras Kreslavsky, Natalie A. Bezman, Joseph C. Sun, Charlie C. Kim, Lewis L. Lanier, Jennifer Miller, Brian Brown, Miriam Merad, Emmanuel L. Gautier, Claudia Jakubzick, Gwendalyn J. Randolph, Francis Kim, Tata Nageswara Rao, Amy Wagers, Tracy Heng, Michio Painter, Jeffrey Ericson, Scott Davis, Ayla Ergun, Michael Mingueneau, Diane Mathis, and Christophe Benoist.",
year = "2013",
month = dec,
day = "1",
doi = "10.1016/j.it.2013.03.004",
language = "English",
volume = "34",
pages = "602--609",
journal = "Trends in Immunology",
issn = "1471-4906",
publisher = "Elsevier Ltd.",
number = "12",
}