Immunological potential of yolk sac cells.

F. Hofman; A. Globerson

doi:10.1007/978-1-4613-4355-4_7

Immunological potential of yolk sac cells.

F. Hofman, A. Globerson

Faculty of Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Mouse yolk sac cells on day 9 of gestation were found to elicit a GVH response, measured by enlargement of the local popliteal lymph nodes. The response cannot be attributed to contaminating maternal cells, since F1 (Balb/c x C57B1) yolk sac cells did not cause a reaction in F1 (Balb/c x C57B1) hosts. On the other hand, yolk sac cells did not elicit a detectable MLC reaction, nor did they respond to PHA or Con A. Hence, mouse yolk sac cells have the potential to express a certain limited array of immunological reactivities, before the development of embryonic thymus and liver.

Original language	English
Pages (from-to)	51-57
Number of pages	7
Journal	Advances in Experimental Medicine and Biology
Volume	66
DOIs	https://doi.org/10.1007/978-1-4613-4355-4_7
State	Published - 1 Jan 1976

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology (all)

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10.1007/978-1-4613-4355-4_7

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title = "Immunological potential of yolk sac cells.",

abstract = "Mouse yolk sac cells on day 9 of gestation were found to elicit a GVH response, measured by enlargement of the local popliteal lymph nodes. The response cannot be attributed to contaminating maternal cells, since F1 (Balb/c x C57B1) yolk sac cells did not cause a reaction in F1 (Balb/c x C57B1) hosts. On the other hand, yolk sac cells did not elicit a detectable MLC reaction, nor did they respond to PHA or Con A. Hence, mouse yolk sac cells have the potential to express a certain limited array of immunological reactivities, before the development of embryonic thymus and liver.",

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AU - Globerson, A.

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N2 - Mouse yolk sac cells on day 9 of gestation were found to elicit a GVH response, measured by enlargement of the local popliteal lymph nodes. The response cannot be attributed to contaminating maternal cells, since F1 (Balb/c x C57B1) yolk sac cells did not cause a reaction in F1 (Balb/c x C57B1) hosts. On the other hand, yolk sac cells did not elicit a detectable MLC reaction, nor did they respond to PHA or Con A. Hence, mouse yolk sac cells have the potential to express a certain limited array of immunological reactivities, before the development of embryonic thymus and liver.

AB - Mouse yolk sac cells on day 9 of gestation were found to elicit a GVH response, measured by enlargement of the local popliteal lymph nodes. The response cannot be attributed to contaminating maternal cells, since F1 (Balb/c x C57B1) yolk sac cells did not cause a reaction in F1 (Balb/c x C57B1) hosts. On the other hand, yolk sac cells did not elicit a detectable MLC reaction, nor did they respond to PHA or Con A. Hence, mouse yolk sac cells have the potential to express a certain limited array of immunological reactivities, before the development of embryonic thymus and liver.

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Immunological potential of yolk sac cells.

Abstract

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