Abstract
Immunological variables were studied in rats chronically exposed to high environmental temperature (35°C). Responses were compared with those of rats at 25°C both fed ad libitum and pair fed to the decreased intake found in heat-exposed rats. Heat-exposed rats showed slower delayed-type hypersensitivity responses to keyhole limpet hemocyasis. They showed lower counts of peripheral blood total T cells (OX19+) as well as helper T cells (W3/25+) and smaller numbers of splenic T cells. The thymus was decreased in size. Increased levels of serum IgG antitetanus toxoid antibodies were found in heat-exposed rats. [3H]-thymidine incorporation into Concanavalin A (ConA)-stimulated splenic lymphocytes was decreased in pair-fed rats but not significantly altered in heat-exposed rats compared with controls. Heat exposure alters some aspects of both cellular and humoral immune function in a manner different from that induced by comparable food restriction without heat exposure.
Original language | English |
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Pages (from-to) | 361-367 |
Number of pages | 7 |
Journal | American Journal of Clinical Nutrition |
Volume | 48 |
Issue number | 2 |
DOIs | |
State | Published - 1 Jan 1988 |
Externally published | Yes |
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics