Immunology, autoimmunity, and autoantibodies in parkinson's disease

Michal Benkler, Nancy Agmon-Levin, Sharon Hassin-Baer, Oren S. Cohen, Oscar Danilo Ortega-Hernandez, Amalia Levy, Samuel Datum Moscavitch, Martine Szyper-Kravitz, Maya Damianovich, Miri Blank, Joab Chapman, Yehuda Shoenfeld

    Research output: Contribution to journalReview articlepeer-review

    29 Scopus citations

    Abstract

    Recent revelations of immune alterations in Parkinson's disease have led to the convergence that an autoimmune mechanism may play a role in the etiopathogenesis of this neurodegenerative disease. In the current study, 77 Parkinson's disease patients and 77 matched healthy controls were analyzed for the presence of seven autoantibodies previously found to be associated with central nervous system manifestations namely: antineuronal-cells, anti-brain lysate, anti-dsDNA, anti-phosphatidylserine, anti-cardiolipin, anti-serotonin, and anti-melanocytes antibodies. Patients underwent systematic assessments of demographics, clinical, and biochemical manifestations. Three autoantibodies were found to be more prevalent among Parkinson's disease patients (antineuronal cells10.3% vs. 1.3%, p=0.017; antibrain lysate 9.1% vs. 1.3%, p=0.032; anti-dsDNA 10.3% vs. 2.6%, p=0.049). Clinical manifestations of Parkinson's disease, particularly dyskinesia and depression, were found to be associated with the presence of these autoantibodies.

    Original languageEnglish
    Pages (from-to)164-171
    Number of pages8
    JournalClinical Reviews in Allergy and Immunology
    Volume42
    Issue number2
    DOIs
    StatePublished - 1 Apr 2012

    Keywords

    • Autoantibodies
    • Autoimmune
    • Depression
    • Dyskinesia
    • Parkinson's disease

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