TY - JOUR
T1 - Immunoregulatory cells in aging mice. I. Concanavalin a-induced and naturally occurring suppressor cells
AU - Globerson, A.
AU - Abel, L.
AU - Barzilay, M.
AU - Zan-Bar, I.
N1 - Funding Information:
This work was supported by the Minerva Foundation, and by Grants No. 1154 (to A. G.) and No. 1155 (to I. Z.) from the Israel Academy of Sciences and Humanities.
PY - 1982/1/1
Y1 - 1982/1/1
N2 - The status of concanavalin A (Con A)-triggered suppressor cells in aging mice was assessed in relation to untreated cells. Spleen cells of (C3H/ebJ×C57BL/6J)F1 and (BALB/cJ × C57BL/6J)F1 aging (20-41 months' old) and young (2-3 months' old) mice were triggered with Con A and examined for their capacity to suppress lymphocyte proliferative responses elicited by mitogens (Con A and phytohemagglutinin), by mixed lymphocyte reactions or by human gamma-globulin. Con A-triggered cells of the aged mice were found to be less efficient suppressors than those of the young, yet the aging mouse spleen cells exerted a more potent suppressive effect than the young, a priori, without pretreatment. Hence, the immune system in aging is characterized by a change in suppressor cell types; the Con A-triggered suppressors diminish and the naturally occurring, untreated ones become abundant.
AB - The status of concanavalin A (Con A)-triggered suppressor cells in aging mice was assessed in relation to untreated cells. Spleen cells of (C3H/ebJ×C57BL/6J)F1 and (BALB/cJ × C57BL/6J)F1 aging (20-41 months' old) and young (2-3 months' old) mice were triggered with Con A and examined for their capacity to suppress lymphocyte proliferative responses elicited by mitogens (Con A and phytohemagglutinin), by mixed lymphocyte reactions or by human gamma-globulin. Con A-triggered cells of the aged mice were found to be less efficient suppressors than those of the young, yet the aging mouse spleen cells exerted a more potent suppressive effect than the young, a priori, without pretreatment. Hence, the immune system in aging is characterized by a change in suppressor cell types; the Con A-triggered suppressors diminish and the naturally occurring, untreated ones become abundant.
UR - http://www.scopus.com/inward/record.url?scp=0020450505&partnerID=8YFLogxK
U2 - 10.1016/0047-6374(82)90013-6
DO - 10.1016/0047-6374(82)90013-6
M3 - Article
AN - SCOPUS:0020450505
SN - 0047-6374
VL - 19
SP - 293
EP - 306
JO - Mechanisms of Ageing and Development
JF - Mechanisms of Ageing and Development
IS - 4
ER -