Immunosuppression by embryonic liver cells

Amiela Globerson, Rolf M. Zinkernagel, Tehila Umiel

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Liver cells from embryonic and newborn mice were found to interfere with mixed lymphocyte culture (MLC) reactions measuring either cytotoxicity by 51Cr release from target cells or 3H-thymidine incorporation. In both experimental systems a suppression was noted when the stimulator cells were syngeneic or unrelated to the liver donor. In addition, 18-day embryonic and neonatal liver cells were found to interfere with production of antibodies to α-dinitrophenyl-poly-L-lysine (α-DNP-PLL) in vitro. These findings conform with the hypothesis that embryonic cells can actively suppress immune reactions and thereby prevent a possible response to self.

Original languageEnglish
Pages (from-to)480-484
Number of pages5
Issue number6
StatePublished - 1 Jan 1975
Externally publishedYes

ASJC Scopus subject areas

  • Transplantation


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