Impact of abnormal karyotype on reproductive outcome in premature ovarian insufficiency

Leonti Grin, Bunpei Ishizuka, Asami Onimaru, Masataka Furuya, Kazuhiro Kawamura

    Research output: Contribution to journalArticlepeer-review

    2 Scopus citations


    Purpose: This study evaluated the reproductive potential of premature ovarian insufficiency (POI) patients with abnormal karyotypes undergoing infertility treatments. Methods: A retrospective analysis of infertility treatments in POI patients with an abnormal karyotype treatment. Clinical and laboratory data were analyzed. Results: The study group was forty-nine POI patients. Follicular growth was achieved in 29% (89/307) controlled ovarian stimulation (COS) cycles in 57% (28/49) of patients. Oocyte retrieval was attempted in 47% (23/49) of patients with a proportion of successful oocyte retrieval per oocyte pick-up (OPU) of 59.4% (41/69). The average number of retrieved oocytes was 2.4 ± 2.7 per patient and fertilization rate was 70.7% (29/41). Embryo transfer (ET) performed in eight patients with a total of nine ET attempts, resulting in 33.3% (3/9) of live birth rate per ET. Three patients delivered a healthy baby (6.1% (3/49) of live birth rate per patient). Mosaic Turner syndrome patients had a longer duration of amenorrhea and lower chances of successful follicular growth with OPU in 35.7% (5/14) of patients, whereas 47XXX had shorter duration of amenorrhea and COS with follicle growth with OPU in 83.3% (5/6). Conclusion: COS might provide an opportunity for POI women with abnormal karyotypes to conceive a biological offspring.

    Original languageEnglish
    Article numbere12471
    JournalReproductive Medicine and Biology
    Issue number1
    StatePublished - 1 Jan 2022


    • chromosomal abnormalities
    • controlled ovarian hyperstimulation
    • karyotype
    • premature ovarian insufficiency
    • turner syndrome

    ASJC Scopus subject areas

    • Reproductive Medicine
    • Cell Biology


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