Impaired glucose transport in polymorphonuclear leukocytes in glycogen storage disease Ib

N. Bashan; R. Potashnik; Y. Hagay; S. W. Moses

doi:10.1007/BF01800068

Impaired glucose transport in polymorphonuclear leukocytes in glycogen storage disease Ib

N. Bashan, R. Potashnik, Y. Hagay, S. W. Moses

Basic Sciences Divisions

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

A study of 2-deoxyglucose transport into polymorphonuclear leukocytes (PMN) was performed in three patients with glycogen storage disease (GSD) type Ib. The rate of 2-deoxyglucose transport into GSD Ib PMN was 30% of that of cells of normal controls. In GSD Ib lymphocytes, transport was normal. K_m for 2-deoxyglucose in the PMN of one patient was within the normal range. The reduced transport was not due to the elevation in K_m for 2-deoxyglucose nor to the decreased rate of phosphorylation of 2-deoxyglucose. The striking limitation of glucose transport across the cell membrane may account for the impairment of leukocyte function which is characteristic of GSD Ib.

Original language	English
Pages (from-to)	234-241
Number of pages	8
Journal	Journal of Inherited Metabolic Disease
Volume	10
Issue number	3
DOIs	https://doi.org/10.1007/BF01800068
State	Published - 1 Sep 1987

ASJC Scopus subject areas

Genetics
Genetics(clinical)

Access to Document

10.1007/BF01800068

Cite this

@article{698eff239dca48d880b510ac76cbd9d0,

title = "Impaired glucose transport in polymorphonuclear leukocytes in glycogen storage disease Ib",

abstract = "A study of 2-deoxyglucose transport into polymorphonuclear leukocytes (PMN) was performed in three patients with glycogen storage disease (GSD) type Ib. The rate of 2-deoxyglucose transport into GSD Ib PMN was 30% of that of cells of normal controls. In GSD Ib lymphocytes, transport was normal. Km for 2-deoxyglucose in the PMN of one patient was within the normal range. The reduced transport was not due to the elevation in Km for 2-deoxyglucose nor to the decreased rate of phosphorylation of 2-deoxyglucose. The striking limitation of glucose transport across the cell membrane may account for the impairment of leukocyte function which is characteristic of GSD Ib.",

author = "N. Bashan and R. Potashnik and Y. Hagay and Moses, {S. W.}",

year = "1987",

month = sep,

day = "1",

doi = "10.1007/BF01800068",

language = "English",

volume = "10",

pages = "234--241",

journal = "Journal of Inherited Metabolic Disease",

issn = "0141-8955",

publisher = "Springer Netherlands",

number = "3",

}

TY - JOUR

T1 - Impaired glucose transport in polymorphonuclear leukocytes in glycogen storage disease Ib

AU - Bashan, N.

AU - Potashnik, R.

AU - Hagay, Y.

AU - Moses, S. W.

PY - 1987/9/1

Y1 - 1987/9/1

N2 - A study of 2-deoxyglucose transport into polymorphonuclear leukocytes (PMN) was performed in three patients with glycogen storage disease (GSD) type Ib. The rate of 2-deoxyglucose transport into GSD Ib PMN was 30% of that of cells of normal controls. In GSD Ib lymphocytes, transport was normal. Km for 2-deoxyglucose in the PMN of one patient was within the normal range. The reduced transport was not due to the elevation in Km for 2-deoxyglucose nor to the decreased rate of phosphorylation of 2-deoxyglucose. The striking limitation of glucose transport across the cell membrane may account for the impairment of leukocyte function which is characteristic of GSD Ib.

AB - A study of 2-deoxyglucose transport into polymorphonuclear leukocytes (PMN) was performed in three patients with glycogen storage disease (GSD) type Ib. The rate of 2-deoxyglucose transport into GSD Ib PMN was 30% of that of cells of normal controls. In GSD Ib lymphocytes, transport was normal. Km for 2-deoxyglucose in the PMN of one patient was within the normal range. The reduced transport was not due to the elevation in Km for 2-deoxyglucose nor to the decreased rate of phosphorylation of 2-deoxyglucose. The striking limitation of glucose transport across the cell membrane may account for the impairment of leukocyte function which is characteristic of GSD Ib.

UR - http://www.scopus.com/inward/record.url?scp=0023502832&partnerID=8YFLogxK

U2 - 10.1007/BF01800068

DO - 10.1007/BF01800068

M3 - Article

AN - SCOPUS:0023502832

SN - 0141-8955

VL - 10

SP - 234

EP - 241

JO - Journal of Inherited Metabolic Disease

JF - Journal of Inherited Metabolic Disease

IS - 3

ER -

Impaired glucose transport in polymorphonuclear leukocytes in glycogen storage disease Ib

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this