@article{d6ba9b9eb7444655a8f551e818d05031,
title = "Impairment of avoidance acquisition and altered regional brain amine levels in mice with uremic endotoxemia",
abstract = "Nephrectomized mice, with highly elevated blood-urea-nitrogen levels by 6 to 7 hr post-treatment, showed impaired acquisition of a passive avoidance response and changes in the ratio of 5-hydroxytryptamine to 5-hydroxyindole-acetic acid and level of norepinephrine in the telencephalon and cerebellum. The regional specificity of uremia-related biochemical changes and behavioral interaction offer bases upon which further investigation of endotoxemia effects on brain metabolism and behavior may be carried out.",
keywords = "Animals, Avoidance Learning, Blood Urea Nitrogen, Brain/metabolism, Brain Chemistry, Cerebellum/metabolism, Diencephalon/metabolism, Hydroxyindoleacetic Acid/analysis, Male, Memory, Mice, Nephrectomy, Norepinephrine/analysis, Serotonin/analysis, Telencephalon/metabolism, Uremia/etiology",
author = "Essman, {W B} and E Heldman",
note = "Funding Information: Six hr post-surgery animals in all three groups were given a single training trial in an apparatus providing for acquisition of a passive avoidance response \[9\]; this consisted of placing a mouse in a clear lucite vestibule adjoining a larger darkened chamber to which access was provided through a 5 cm dia. hole. On stepping into the large chamber an animal received a scrambled 3.0 ma shock delivered through a grid floor to the paws for 3 sec. Following the training trial 0.2 - 0.3 ml of fresh blood was obtained by cardiac puncture from one group of nephrecto- 1This work was supported, in part by Grants HD-03493-03 and Biomedical Support Grant 5-S05-FR-07064-05 from the National Institutes of Health. The authors wish to acknowledge the technical assistance of J. Heldman and C. Antzelevitch.",
year = "1972",
month = jan,
doi = "10.1016/0031-9384(72)90142-4",
language = "אנגלית",
volume = "8",
pages = "143--6",
journal = "Physiology and Behavior",
issn = "0031-9384",
publisher = "Elsevier Inc.",
number = "1",
}