Nephrectomized mice, with highly elevated blood-urea-nitrogen levels by 6 to 7 hr post-treatment, showed impaired acquisition of a passive avoidance response and changes in the ratio of 5-hydroxytryptamine to 5-hydroxyindole-acetic acid and level of norepinephrine in the telencephalon and cerebellum. The regional specificity of uremia-related biochemical changes and behavioral interaction offer bases upon which further investigation of endotoxemia effects on brain metabolism and behavior may be carried out.
- Avoidance Learning
- Blood Urea Nitrogen
- Brain Chemistry
- Hydroxyindoleacetic Acid/analysis