Impairment of cellular immunity in patients with malignant external otitis

I. Yust, C. Radiano, B. Tartakovsky, A. Tanay, E. Shanon, S. Segal

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Immunological studies were performed on 4 elderly diabetic patients with Malignant External Otitis caused by Pseudomonas aeruginosa. Impairment of cellular immunity was found. Skin tests for delayed hyper-sensitivity to PPD, SK-SD and Mumps antigen were negative and stimulation rates of peripheral blood lymphocytes by PHA, Con-A and PWM were depressed in all 4 patients. Serum immunoglobulins and complement levels were normal exept in one case in which para-protein IgG was found. Peripheral blood lymphoid cell markers and the neutrophil nitroblue tetrazolium (NBT) test were within normal limits in the 2 patients tested. These results indicate that cellular immune deficiency predisposes to the development of Malignant External Otitis in elderly diabetic patients.

Original languageEnglish
Pages (from-to)398-403
Number of pages6
JournalActa Oto-Laryngologica
Issue number1-6
StatePublished - 1 Jan 1980
Externally publishedYes

ASJC Scopus subject areas

  • Otorhinolaryngology


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