Impairment of platelet aggregation by Echis colorato venom mediated by L-amino acid oxidase or H2O2

I. Nathan, A. Dvilansky, T. Yirmiyahu, M. Aharon, A. Livne

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Echis colorata bites cause impairment of platelet aggregation and hemostatic disorders. The mechanism by which the snake venom inhibits platelet aggregation was studied. Upon fractionation, aggregation impairment activity and L-amino acid oxidase activity were similarly separated from the crude venom, unlike other venom enzymes. Preparations of L-amino acid oxidase from E. colorata and from Crotalus adamanteus replaced effectively the crude E. colorata venom in impairment of platelet aggregation. Furthermore, different treatments known to inhibit L-amino acid oxidase reduced in parallel the oxidase activity and the impairment potency of both the venom and the enzyme preparation. H2O2 mimicked characteristically the impairment effects of L-amino acid oxidase and the venom. Catalase completely abolished the impairment effects of the enzyme and the venom. It is concluded that hydrogen peroxide formed by the venom L-amino acid oxidase plays a role in affecting platelet aggregation and thus could contribute to the extended bleeding typical to persons bitten by E. colorata.

Original languageEnglish
Pages (from-to)277-282
Number of pages6
JournalThrombosis and Haemostasis
Issue number3
StatePublished - 1 Jan 1982

ASJC Scopus subject areas

  • Hematology


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