TY - JOUR
T1 - Impairment of the hypothalamo-pituitary-ovarian axis of the athymic "nude" mouse
AU - Weinstein, Y.
N1 - Funding Information:
This work was supportedb y grantsf rom the IsraelC ommissiofno r BasicR esearch (to Y. W.), and the Ford Foundationa nd the PopulationC ouncil, N.Y. (to H. R. Lindner).
PY - 1978/1/1
Y1 - 1978/1/1
N2 - Pituitary and serum levels of LH and FSH and hypothalamic GnRH content were measured in acyclic, congenitally athymic (nu/nu) female mice. No significant differences were found between athymic and normal diostrous mice of the same age (3 months). The serum LH level of the athymic mouse failed to increase 6 days after ovariectomy, but increased in response to injection of GnRH. The results suggest that the athymic nude mice suffer from impairment of hypothalamic control of the pituitary.
AB - Pituitary and serum levels of LH and FSH and hypothalamic GnRH content were measured in acyclic, congenitally athymic (nu/nu) female mice. No significant differences were found between athymic and normal diostrous mice of the same age (3 months). The serum LH level of the athymic mouse failed to increase 6 days after ovariectomy, but increased in response to injection of GnRH. The results suggest that the athymic nude mice suffer from impairment of hypothalamic control of the pituitary.
UR - http://www.scopus.com/inward/record.url?scp=0017810814&partnerID=8YFLogxK
U2 - 10.1016/0047-6374(78)90007-6
DO - 10.1016/0047-6374(78)90007-6
M3 - Article
AN - SCOPUS:0017810814
SN - 0047-6374
VL - 8
SP - 63
EP - 68
JO - Mechanisms of Ageing and Development
JF - Mechanisms of Ageing and Development
IS - C
ER -