Impedance study of the hybrid molecule alginate-pyrrole: Demonstration as host matrix for the construction of a highly sensitive amperometric glucose biosensor

Khalil Abu-Rabeah, Robert S. Marks

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

The aim of this paper is to report the characterization and application of a new and attractive hybrid molecule (alginate modified with pyrrole) alginate-pyrrole (Alg-py) with glucose oxidase (GOx) to create a highly responsive glucose biosensor. The biosensor was built by covalent attachment of GOx with the Alg-py matrix, followed by pyrrole polymerization, then casting the biocomposite onto the surface of a platinum electrode (Pt). The unique three-dimensional structure, porous morphology, conductive setup, mechanical firmness and biocompatibility resulted in low response time (4 s), high sensitivity value (16μAmM-1 cm-2) and a very low enzyme load (9.2 U).

Original languageEnglish
Pages (from-to)516-522
Number of pages7
JournalSensors and Actuators, B: Chemical
Volume136
Issue number2
DOIs
StatePublished - 1 Jan 2009

Keywords

  • Alginate-pyrrole
  • Biosensor
  • Conductive polymers
  • Glucose oxidase
  • Hydrogel

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