TY - JOUR
T1 - Implication of Ceramide Kinase/C1P in Cancer Development and Progression
AU - Camacho, Laura
AU - Ouro, Alberto
AU - Gomez-Larrauri, Ana
AU - Carracedo, Arkaitz
AU - Gomez-Muñoz, Antonio
N1 - Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/1/1
Y1 - 2022/1/1
N2 - Cancer cells rewire their metabolic programs to favor biological processes that promote cell survival, proliferation, and dissemination. Among this relevant reprogramming, sphingolipid metabolism provides metabolites that can favor or oppose these hallmarks of cancer. The sphingolipid ceramide 1-phosphate (C1P) and the enzyme responsible for its biosynthesis, ceramide kinase (CERK), are well established regulators of cell growth and survival in normal, as well as malignant cells through stress-regulated signaling pathways. This metabolite also promotes cell survival, which has been associated with the feedback regulation of other antitumoral sphingolipids or second messengers. C1P also regulates cancer cell invasion and migration of different types of cancer, including lung, breast, pancreas, prostate, or leukemia cells. More recently, CERK and C1P have been implicated in the control of inflammatory responses. The present review provides an updated view on the important role of CERK/C1P in the regulation of cancer cell growth, survival, and dissemination.
AB - Cancer cells rewire their metabolic programs to favor biological processes that promote cell survival, proliferation, and dissemination. Among this relevant reprogramming, sphingolipid metabolism provides metabolites that can favor or oppose these hallmarks of cancer. The sphingolipid ceramide 1-phosphate (C1P) and the enzyme responsible for its biosynthesis, ceramide kinase (CERK), are well established regulators of cell growth and survival in normal, as well as malignant cells through stress-regulated signaling pathways. This metabolite also promotes cell survival, which has been associated with the feedback regulation of other antitumoral sphingolipids or second messengers. C1P also regulates cancer cell invasion and migration of different types of cancer, including lung, breast, pancreas, prostate, or leukemia cells. More recently, CERK and C1P have been implicated in the control of inflammatory responses. The present review provides an updated view on the important role of CERK/C1P in the regulation of cancer cell growth, survival, and dissemination.
KW - Cancer cell signaling
KW - Ceramide kinase
KW - Ceramide-1-phosphate
KW - Invasion and dissemination
KW - Tumor cell proliferation
UR - http://www.scopus.com/inward/record.url?scp=85122074566&partnerID=8YFLogxK
U2 - 10.3390/cancers14010227
DO - 10.3390/cancers14010227
M3 - Review article
AN - SCOPUS:85122074566
SN - 2072-6694
VL - 14
JO - Cancers
JF - Cancers
IS - 1
M1 - 227
ER -