Implication of Ceramide Kinase/C1P in Cancer Development and Progression

Laura Camacho, Alberto Ouro, Ana Gomez-Larrauri, Arkaitz Carracedo, Antonio Gomez-Muñoz

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations

Abstract

Cancer cells rewire their metabolic programs to favor biological processes that promote cell survival, proliferation, and dissemination. Among this relevant reprogramming, sphingolipid metabolism provides metabolites that can favor or oppose these hallmarks of cancer. The sphingolipid ceramide 1-phosphate (C1P) and the enzyme responsible for its biosynthesis, ceramide kinase (CERK), are well established regulators of cell growth and survival in normal, as well as malignant cells through stress-regulated signaling pathways. This metabolite also promotes cell survival, which has been associated with the feedback regulation of other antitumoral sphingolipids or second messengers. C1P also regulates cancer cell invasion and migration of different types of cancer, including lung, breast, pancreas, prostate, or leukemia cells. More recently, CERK and C1P have been implicated in the control of inflammatory responses. The present review provides an updated view on the important role of CERK/C1P in the regulation of cancer cell growth, survival, and dissemination.

Original languageEnglish
Article number227
JournalCancers
Volume14
Issue number1
DOIs
StatePublished - 1 Jan 2022
Externally publishedYes

Keywords

  • Cancer cell signaling
  • Ceramide kinase
  • Ceramide-1-phosphate
  • Invasion and dissemination
  • Tumor cell proliferation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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